CLOXAZOLAM
- CAS NO.:24166-13-0
- Empirical Formula: C17H14Cl2N2O2
- Molecular Weight: 349.21
- MDL number: MFCD00868152
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:36
What is CLOXAZOLAM?
Originator
Sepazon,Sankyo,Japan,1974
The Uses of CLOXAZOLAM
CLOXAZOLAM is a benzodiazepine derivative with anxiolytic, hypnotic and antihypertensive properties used as an anti-anxiety drug. It is metabolized into the active metabolite Delorezepam (D230675). Controlled Subs tance.
Definition
ChEBI: Cloxazolam is an oxazolobenzodiazepine and a hemiaminal ether.
Manufacturing Process
As described in US Patent 3,772,371: To a solution of 5.8 g of 5-chloro-2-
bromoacetylamino-o-chlorobenzophenone in 120 ml of ethanol were added
0.95 g of ethanolamine and 1.3 g of sodium acetate. The resulting mixture
was heated under reflux for 16 hours.
After completion of the reaction, the solvent was distilled off and the residue
was extracted with dichloromethane. The extract was washed with water,
dried over anhydrous sodium sulfate and the solvent was distilled off to give
3.25 g of the desired product melting at 202° to 204°C with decomposition.
Therapeutic Function
Tranquilizer
Properties of CLOXAZOLAM
Melting point: | 202-204° (dec) |
Boiling point: | 172°C (rough estimate) |
Density | 1.4125 (rough estimate) |
refractive index | 1.6100 (estimate) |
pka | 12.70±0.40(Predicted) |
CAS DataBase Reference | 24166-13-0 |
Safety information for CLOXAZOLAM
Computed Descriptors for CLOXAZOLAM
New Products
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