Closantel

Synonym(s):N-[5-Chloro-4-(4-chloro-α-cyanobenzyl)-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide;5′-Chloro-4′-(4-chloro-α-cyanobenzyl)-3,5-diiodo-2′-methylsalicylanilide

CAS NO.：57808-65-8
Empirical Formula: C22H14Cl2I2N2O2
Molecular Weight: 663.07
MDL number: MFCD00661151
EINECS: 260-967-1
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-06 18:33:45

What is Closantel?

Chemical properties

White to light yellow powder

The Uses of Closantel

antianginal, antihypertensive

What are the applications of Application

Closantel is potentially useful for studying P-glycoprotein interactions in vitro

Definition

ChEBI: N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide is an aromatic amide resulting from the formal condensation of the carboxy group of 3,5-diiodosalicylic acid with the amino group of aniline substituted at positions 2, 4, and 5 by methyl, (4-chlorophenyl)(cyano)methyl, and methyl groups respectively. It is a nitrile, a member of phenols, an organoiodine compound, a monocarboxylic acid amide, an aromatic amide and a member of monochlorobenzenes.

Properties of Closantel

Melting point:	217.8°
Boiling point:	590.5±50.0 °C(Predicted)
Density	1.8759 (estimate)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml
pka	5.99±0.48(Predicted)
form	neat
form	Solid
color	White to off-white
CAS DataBase Reference	57808-65-8(CAS DataBase Reference)

Safety information for Closantel

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral H413:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P273:Avoid release to the environment.