Clorsulon

Description

Clorsulon is a sulfonamide antiparasitic agent. It induces swelling and blebbing and reduces motility of F. hepatica mature flukes when used at a concentration of 10 μg/ml. In vivo, clorsulon (3.5-15 mg/kg) reduces the number of flukes in a goat model of F. hepatica infection. It completely eradicates naturally acquired F. hepatica adult flukes in sheep and cattle when administered at a dose of 7 mg/kg. Formulations containing clorsulon have been used in the treatment of liver flukes in sheep and cattle.

Chemical properties

Crystalline Solid

The Uses of Clorsulon

A benzenedisulfonamide derivative with fasciolicidal activity. Anthelmintic (Trematodes)

The Uses of Clorsulon

analgesic, antiinflammatory

The Uses of Clorsulon

A benzenedisulfonamide derivative with fasciolicidal activity. Anthelmintic (Trematodes).

What are the applications of Application

Clorsulon is A benzenedisulfonamide derivative with fasciolicidal activity

Definition

ChEBI: 4-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamide is a sulfonamide and a member of benzenes.

brand name

Curatrem [Veterinary] (Merial).

Veterinary Drugs and Treatments

Clorsulon is approved for use in the treatment of immature and adult forms of Fasciola hepatica (Liver fluke) in cattle. It is not effective against immature flukes less than 8 weeks old. It also has activity against Fasciola gigantica. Although not approved, the drug has been used in practice in various other species (e.g., sheep, llamas). It has activity against F. magna in sheep, but is not completely effective in eradicating the organism after a single dose, thus severely limiting its clinical usefulness against this parasite. Clorsulon is also not effective against the rumen fluke (Paramphistomum).