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HomeProduct name listCloquintocet-mexyl

Cloquintocet-mexyl

  • CAS NO.:99607-70-2
  • Empirical Formula: C18H22ClNO3
  • Molecular Weight: 335.83
  • MDL number: MFCD01632329
  • EINECS: 619-447-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-18 14:08:52
Cloquintocet-mexyl Structural

What is Cloquintocet-mexyl?

Description

Cloquintocet-mexyl is a colourless crystalline herbicide safener. It is categorized as Class III toxin.

Chemical properties

beige solid

The Uses of Cloquintocet-mexyl

Cloquintocet-mexyl is a herbicide. It is used to control coarse annual grass of the family poaceae (gramineae). lt was developed by the swiss ciba geigy in the 1980s and the patent has expired.

The Uses of Cloquintocet-mexyl

Cloquintocet-mexyl is used as a herbicide.

Definition

ChEBI: Heptan-2-yl [(5-chloroquinolin-8-yl)oxy]acetate is a member of the class of quinolines that is quinoline which is substituted by a chloro group at position 5 and by a 2-[(heptan-2-yl)oxy]-2-oxoethoxy group at position 8. It is an aromatic ether, an organochlorine compound, a member of quinolines and a carboxylic ester.

Agricultural Uses

Cloquintocet-mexyl is a safener that can be used in conjunction with various herbicides to reduce phytotoxicity to crops. Though effective as a safener, the manufacture, storage, and use of cloquintocet-mexyl containing products can present challenges owing to its sensitivity to water and its low melting temperature (i.e., 61-69° C. for technical material). When products containing cloquintocet-mexyl are prepared, stored, or used in the presence of water, cloquin tocet-mexyl can undergo hydrolysis to form cloquintocet acid, and/or form a needle-shaped, crystalline hydrate that can, lead to clogged spray nozzles during spray applications and/or possibly increased levels of crop phytotoxicity.

Carcinogenicity

In accordance with the EPA Proposed EPA Weight-of-the-Evidence Categories, August 1999, the HIARC classified cloquintocet-mexyl as "not likely to be a human carcinogen." Carcinogenicity studies in rats and mice did not show increased incidence of spontaneous tumor formation. With negative mutagenic test battery, it is suggested that cloquintocet-mexyl (CGA 185072) is not likely to be a human carcinogen.

Metabolism

Metabolism studies in rats indicated that approximately 40% of the administered dose of cloquintocet-mexyl was absorbed through the gastrointestinal tract and subsequently excreted via the urine. Fecal excretion accounted for approximately 60% of the administered dose. The chemical was rapidly eliminated (more than 80% of the administered dose) via feces and urine within 48 hours post-dosing. Sex, dosing regime, and dose levels had little effect on the excretion pattern. Excretion patterns were similar between the biliary cannulated and non-cannulated animals indicating that there was no enterohepatic circulation of the chemical. Three days after administration, tissue radioactivity accounted for less than 0.3% of the administered dose (or was non-detectable) and was not detectable in the expired air. At day three post-dosing, most tissue residues of radioactivity were below the limit of detection. The major metabolic pathway of cloquintocet-mexyl was ester hydrolysis to yield 5-chloro-8-quinolinoxy acetic acid, the major metabolite in the fecal and urinary pools.

Toxicity evaluation

Cloquintocet-mexyl has a low order of acute oral, dermal, and inhalation toxicity. It is slightly irritating to the eyes and non-irritating to the skin. Cloquintocet-mexyl is a skin sensitizer. The chemical is not genotoxic and is not a reproductive and developmental toxicant. There is no evidence of neurotoxicity in the available studies. Cloquintocet-mexyl is classified as “not likely to be a human carcinogen.” The main metabolite for cloquintocet-mexyl is 5-chloro-8-quin-linoxyacetic acid, and testing on the metabolite is part of the toxicology database for cloquintocet-mexyl.

Properties of Cloquintocet-mexyl

Melting point: 69°
Boiling point: 448.4±30.0 °C(Predicted)
Density  1.163±0.06 g/cm3(Predicted)
vapor pressure  0-54.4Pa at 25-185.9℃
storage temp.  Sealed in dry,2-8°C
solubility  Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
form  neat
pka 1.94±0.29(Predicted)
form  Solid
color  White to Off-White
Merck  14,2401
Stability: Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference 99607-70-2(CAS DataBase Reference)
EPA Substance Registry System Cloquintocet-mexyl (99607-70-2)

Safety information for Cloquintocet-mexyl

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Environment
GHS09
GHS Hazard Statements H317:Sensitisation, Skin
H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P272:Contaminated work clothing should not be allowed out of the workplace.
P273:Avoid release to the environment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

Computed Descriptors for Cloquintocet-mexyl

Cloquintocet-mexyl manufacturer

United Phosphorus Limited

1Y
Phone:+91-9004390689
Whatsapp: +91 9004390689
product: 99607-70-2 98%
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Bharat Rasayan

1Y
Phone:+91-9619772584
Whatsapp: +91-9619772584
product: Cloquintocet-mexyl 98%
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Auro Pharmaceuticals And Fine Chemicals Pvt Ltd

1Y
Phone:+91-8087324189
Whatsapp: +91- 8087324189
product: Cloquintocet-mexyl 99607-70-2 98%
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Bhagiradha Chemicals And Industries Limited

1Y
Phone:+914042221212
product: 99607-70-2 Cloquintocet-mexyl 98%
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HPM Chemicals And Fertilizers Ltd

1Y
Phone:+91-8275418788
Whatsapp: +91- 8275418788
product: 99607-70-2 98%
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Shiva Pharmachem Pvt Ltd

1Y
Phone:+91-2652321418
product: Cloquintocet-mexyl 99%
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Imkemex

Maharashtra
product: Cloquintocet-mexyl
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