Clobetasone butyrate

Synonym(s):21-Chloro-9-fluoro-17-hydroxy-16-methylpregna-1,4-diene-3,11,20-trione 17-butyrate

CAS NO.：25122-57-0
Empirical Formula: C26H32ClFO5
Molecular Weight: 478.98
MDL number: MFCD00133196
EINECS: 246-635-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 20:33:22

What is Clobetasone butyrate?

Chemical properties

White or almost white powder.

The Uses of Clobetasone butyrate

Glucocorticoid; anti-inflammmatory.

What are the applications of Application

Clobetasone butyrate is an antiinflammatory synthetic glucocorticoid

Definition

ChEBI: Clobetasone butyrate is an organic molecular entity.

Mechanism of action

Topical corticosteroids (Clobetasone butyrate) inhibit the migration of macrophages and leukocytes into areas of inflamed skin by reversing vascular dilation and permeability, resulting in decreased erythema, edema and pruritus.

Side Effects

Some people get a burning or stinging feeling for a few minutes when they put clobetasone cream or ointment on their skin. Clobetasone cream contains cetostearyl alcohol and chlorocresol, which may cause local skin reactions or allergic reactions.

Properties of Clobetasone butyrate

Melting point:	90-100°
Boiling point:	573.3±50.0 °C(Predicted)
Density	1.1736 (estimate)
storage temp.	Refrigerator, Under Inert Atmosphere
solubility	Practically insoluble in water, freely soluble in acetone and in methylene chloride, slightly soluble in ethanol (96 per cent).
form	neat
form	Solid
color	White to Off-White
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference	25122-57-0(CAS DataBase Reference)

Safety information for Clobetasone butyrate

Signal word	Warning
Pictogram(s)	Health Hazard GHS08
GHS Hazard Statements	H351:Carcinogenicity
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for Clobetasone butyrate

InChIKey	FBRAWBYQGRLCEK-JGSYYNBSNA-N
SMILES	[C@]1(C(=O)CCl)(OC(=O)CCC)[C@@H](C)C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)C(=O)C[C@]12C \|&1:0,11,14,16,26,28,33,r\|