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HomeProduct name listCLASTO-LACTACYSTIN BETA-LACTONE

CLASTO-LACTACYSTIN BETA-LACTONE

Synonym(s):(1R,4R,5S)-1-[(1S)-1-Hydroxy-2-Methylpropyl]-4-Methyl-6-Oxa-2-Azabicyclo[3.2.0]Heptane-3,7-Dione;clasto-Lactacystin β-Lactone - CAS 154226-60-5 - Calbiochem;Omuralide;Omuralide, Proteasome Inhibitor IX

CLASTO-LACTACYSTIN BETA-LACTONE Structural

What is CLASTO-LACTACYSTIN BETA-LACTONE?

Chemical properties

White Solid

The Uses of CLASTO-LACTACYSTIN BETA-LACTONE

clasto-Lactacystin beta-lactone is a 20S proteasome and cathepsin A inhibitor.

The Uses of CLASTO-LACTACYSTIN BETA-LACTONE

A cell permeable, irreversible proteasome inhibitor. It is 20-fold more potent than Lactacystin. Lactacytstin spontaneously converts to clasto-lactacystin in biological systems. Clasto-lactacystin is the only cell permeable form of lactacystin. Induces neurite growth and inhibits cell cycle progression similar to lactacytin.

The Uses of CLASTO-LACTACYSTIN BETA-LACTONE

Clasto-Lactacystin β-lactone has been used as a proteasomal inhibitor.

What are the applications of Application

clasto-Lactacystin β-Lactone is an active species of lactacystin proteasome inhibition

Biological Activity

cell-permeable. a highly specific, potent and irreversible proteasome inhibitor. lactacystin (cat. no. 1709-200) acts as a precursor for clasto-lactacystin β-lactone and the latter compound is at least 10 times more active than the parent lactacystin

Biochem/physiol Actions

Clasto-Lactacystin β-lactone (cLβL) is synthesized from lactacystin. It is cell-permeable and cLβL acts on the N-terminal threonine of subunit proteasome β -subunit X It also inhibits 20S proteasome activity in Haloferax volcanii?by acting in the N-threonine residue of the? β -type subunits.

Properties of CLASTO-LACTACYSTIN BETA-LACTONE

Melting point: 186-187°C
storage temp.  -20°C
solubility  DMF, Ethanol, Hot Ethyl Acetate, Methanol, Pyridine
form  White solid
color  White

Safety information for CLASTO-LACTACYSTIN BETA-LACTONE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H319:Serious eye damage/eye irritation
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for CLASTO-LACTACYSTIN BETA-LACTONE

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