CLASTO-LACTACYSTIN BETA-LACTONE
Synonym(s):(1R,4R,5S)-1-[(1S)-1-Hydroxy-2-Methylpropyl]-4-Methyl-6-Oxa-2-Azabicyclo[3.2.0]Heptane-3,7-Dione;clasto-Lactacystin β-Lactone - CAS 154226-60-5 - Calbiochem;Omuralide;Omuralide, Proteasome Inhibitor IX
- CAS NO.:154226-60-5
- Empirical Formula: C10H15NO4
- Molecular Weight: 213.23
- MDL number: MFCD01076526
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:03:06
What is CLASTO-LACTACYSTIN BETA-LACTONE?
Chemical properties
White Solid
The Uses of CLASTO-LACTACYSTIN BETA-LACTONE
clasto-Lactacystin beta-lactone is a 20S proteasome and cathepsin A inhibitor.
The Uses of CLASTO-LACTACYSTIN BETA-LACTONE
A cell permeable, irreversible proteasome inhibitor. It is 20-fold more potent than Lactacystin. Lactacytstin spontaneously converts to clasto-lactacystin in biological systems. Clasto-lactacystin is the only cell permeable form of lactacystin. Induces neurite growth and inhibits cell cycle progression similar to lactacytin.
The Uses of CLASTO-LACTACYSTIN BETA-LACTONE
Clasto-Lactacystin β-lactone has been used as a proteasomal inhibitor.
What are the applications of Application
clasto-Lactacystin β-Lactone is an active species of lactacystin proteasome inhibition
Biological Activity
cell-permeable. a highly specific, potent and irreversible proteasome inhibitor. lactacystin (cat. no. 1709-200) acts as a precursor for clasto-lactacystin β-lactone and the latter compound is at least 10 times more active than the parent lactacystin
Biochem/physiol Actions
Clasto-Lactacystin β-lactone (cLβL) is synthesized from lactacystin. It is cell-permeable and cLβL acts on the N-terminal threonine of subunit proteasome β -subunit X It also inhibits 20S proteasome activity in Haloferax volcanii?by acting in the N-threonine residue of the? β -type subunits.
Properties of CLASTO-LACTACYSTIN BETA-LACTONE
Melting point: | 186-187°C |
storage temp. | -20°C |
solubility | DMF, Ethanol, Hot Ethyl Acetate, Methanol, Pyridine |
form | White solid |
color | White |
Safety information for CLASTO-LACTACYSTIN BETA-LACTONE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for CLASTO-LACTACYSTIN BETA-LACTONE
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