CIS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE
- CAS NO.：13149-00-3
- Empirical Formula: C8H10O3
- Molecular Weight: 154.16
- MDL number: MFCD00005926
- EINECS: 236-086-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-07-27 17:31:07
What is CIS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE?
Chemical properties
white to almost white cryst. low melting solid
The Uses of CIS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE
(3aR,7aS)-rel-Hexahydro-1,3-isobenzofurandione is a reagent used in the synthesis of Pregabalin (P704800), a GABA analogue used as an anticonvulsant. Also used to prepare P2X7 receptor antagonists.
Purification Methods
It has been obtained by heating the trans-acid or anhydride at 200o. Crystallise it from *C6H6/Et2O or distil it. [Kohler & Jansen J Am Chem Soc 60 2145 1938, Abell J Org Chem 22 769 1957, Beilstein 17 II 452, 17 III/IV 5931.]
Properties of CIS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE
| Melting point: | 32-34 °C(lit.) |
| Boiling point: | 158 °C17 mm Hg(lit.) |
| Density | 1.23 |
| refractive index | 1.4750 (estimate) |
| Flash point: | >230 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Crystalline Low Melting Solid |
| color | White to almost white |
| Sensitive | Moisture Sensitive |
| BRN | 83214 |
| Stability: | Moisture Sensitive |
| CAS DataBase Reference | 13149-00-3(CAS DataBase Reference) |
Safety information for CIS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Health Hazard GHS08 |
| GHS Hazard Statements |
H317:Sensitisation, Skin H318:Serious eye damage/eye irritation H334:Sensitisation, respiratory |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P272:Contaminated work clothing should not be allowed out of the workplace. P280:Wear protective gloves/protective clothing/eye protection/face protection. P284:Wear respiratory protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P501:Dispose of contents/container to..… |
Computed Descriptors for CIS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE
New Products
ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound ARelated products of tetrahydrofuran
You may like
-
Cis-1,2-cyclohexanedicarboxylic anhydride 98% CAS 13149-00-3View Details
13149-00-3 -
cis-1,2-Cyclohexanedicarboxylic Anhydride CAS 13149-00-3View Details
13149-00-3 -
Dechloro DesloratadineView Details -
Dehydro DesloratadineView Details -
Edoxaban Impurity 57View Details
2089454-69-1 -
Empagliflozin Bromo ImpurityView Details -
Glycopyrronium Bromide EP Impurity IView Details
1404617-94-2 -
Ipratropium EP Impurity BView Details
58073-59-9
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.