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HomeProduct name listCIRAZOLINE HYDROCHLORIDE

CIRAZOLINE HYDROCHLORIDE

  • CAS NO.:40600-13-3
  • Empirical Formula: C13H17ClN2O
  • Molecular Weight: 252.74
  • MDL number: MFCD00274034
  • EINECS: 2549953
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-28 23:16:16
CIRAZOLINE HYDROCHLORIDE Structural

What is CIRAZOLINE HYDROCHLORIDE?

Description

Cirazoline is an α1-adrenergic receptor (α1-AR) agonist (Kis = 120, 960, and 660 nM for recombinant α1A-, α1B-, and α1D-ARs, respectively, in CHO cell membranes). It acts as a full agonist at α1A- and a partial agonist at α1B- and α1D-ARs in vitro (EC50s = 70.7, 79.4, and 239.8 nM, respectively). It also acts as an antagonist at α2-ARs with a pA2 value of 7.56 to inhibit the norepinephrine-induced twitch response in isolated pig ileum. Cirazoline (0.01-1 μg/kg) decreases blood pressure when administered via microinjection to the nucleus reticularis lateralis (NRL) of anesthetized normotensive cats. It enhances spatial memory and reduces depressive- and anxiety-like behavior in mice when administered at a concentration of 10 mg/L in drinking water for 2-9 months. It also enhances performance in the variable delayed response task in aged rhesus monkeys at high doses of 1-10 μg/kg but impairs performance at lower doses of 0.01-1 μg/kg.

The Uses of CIRAZOLINE HYDROCHLORIDE

Cirazoline hydrochloride has been used to activate the α1-noradrenergic receptors and to study the inhibitory effect of neurokinin1 (NK1) antagonists on respiratory activity using the brainstem transverse slice.

What are the applications of Application

Cirazoline hydrochloride is a selective α1 agonist

Biological Activity

Selective α 1 agonist. Also available as part of the α 1 -Adrenoceptor Tocriset™ and Mixed Adrenergic Tocriset™ .

Biochem/physiol Actions

Cirazoline is a selective α1-adrenoceptor agonist and also a non-selective ligand for the imidazoline binding site. Cirazoline dereases spatial working memory performance in aged monkeys.

storage

Store at RT

Properties of CIRAZOLINE HYDROCHLORIDE

storage temp.  Store at RT
solubility  H2O: >35 mg/mL
form  solid
color  white

Safety information for CIRAZOLINE HYDROCHLORIDE

Computed Descriptors for CIRAZOLINE HYDROCHLORIDE

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