Cholesteryl acetate

Synonym(s):3β-Acetoxy-5-cholestene;3β-Hydroxy-5-cholestene 3-acetate;5-Cholesten-3β-ol 3-acetate

CAS NO.：604-35-3
Empirical Formula: C29H48O2
Molecular Weight: 428.69
MDL number: MFCD00003636
EINECS: 210-066-4
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-26 16:58:18

What is Cholesteryl acetate?

Chemical properties

white fine crystalline powder or needles

The Uses of Cholesteryl acetate

Cholesteryl acetate is derived from cholesterol, which is a major component of all biological membranes. Approximately 25% of total brain lipid is made up of cholesterol, which is the principal sterol of higher animals. Cholesterol is found in all body tissues, with particularly high concentrations in the brain, spinal cord, and animal fats or oils. Additionally, cholesterol is the main constituent of gallstones.

The Uses of Cholesteryl acetate

Cholesteryl acetate is used in cosmetics, wrist watches, thermometers, propane tank volume indicators, video displays, pharmaceuticals.

Definition

ChEBI: Cholesteryl acetate is a cholesterol ester obtained by formal acylation of the hydroxy group of cholesterol by acetic acid. It has a role as a human metabolite. It is a cholesteryl ester and an acetate ester.

Purification Methods

Crystallise the acetate from n-pentanol or Me2CO. Also purify it by chromatography through silica gel and eluting with MeOH. [Beilstein 6 III 2607, 6 IV 4004.]

Properties of Cholesteryl acetate

Melting point:	112-114 °C (lit.)
Boiling point:	483.49°C (rough estimate)
alpha	-44 º (c=2, CHCl3)
Density	0.9935 (rough estimate)
refractive index	1.5045 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	insoluble
form	Solid
color	White to Off-White
optical activity	[α]24/D 44°, c = 2 in chloroform
Water Solubility	insoluble
Merck	14,2201
BRN	2064235
Stability:	Hygroscopic
CAS DataBase Reference	604-35-3(CAS DataBase Reference)
NIST Chemistry Reference	Cholesteryl acetate(604-35-3)
EPA Substance Registry System	Cholest-5-en-3-ol (3.beta.)-, acetate (604-35-3)

Safety information for Cholesteryl acetate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.