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HomeProduct name listCHEMBRDG-BB 5280909

CHEMBRDG-BB 5280909

Synonym(s):1-Methyl-5-nitro-3-phenyl-1H-indole-2-methanol;VU0099704

CHEMBRDG-BB 5280909 Structural

What is CHEMBRDG-BB 5280909?

Description

ML-354 is an indole-based, proteinase-activated receptor 4 (PAR4) antagonist (IC50 = 140 nM) that exhibits 71-fold selectivity for PAR4 over PAR1 (IC50 = 10 μM) in isolated human platelets.

The Uses of CHEMBRDG-BB 5280909

ML-354 is a selective protease activated receptor 4 ( PAR-4) antagonist used for its antithrombotic effects.

Biochem/physiol Actions

ML354 is a potent and selective PAR4 (protease activated receptor-4) antagonist.

storage

Store at -20°C

References

[1]. wen, w., young, s., duvernay, m., schulte, m., nance, k., & melancon, b. et al. substituted indoles as selective protease activated receptor 4 (par-4) antagonists: discovery and sar of ml354. bioorganic & medicinal chemistry letters. 2014; 24(19): 4708-4713.

Properties of CHEMBRDG-BB 5280909

Melting point: 178-179 °C(Solv: 1,4-dioxane (123-91-1))
Boiling point: 544.0±50.0 °C(Predicted)
Density  1.29±0.1 g/cm3(Predicted)
storage temp.  -20°C
solubility  ≤2mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
pka 14.47±0.10(Predicted)
form  powder
color  white to beige

Safety information for CHEMBRDG-BB 5280909

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H301:Acute toxicity,oral
Precautionary Statement Codes P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Computed Descriptors for CHEMBRDG-BB 5280909

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