CHEMBRDG-BB 5280909
Synonym(s):1-Methyl-5-nitro-3-phenyl-1H-indole-2-methanol;VU0099704
- CAS NO.：89159-60-4
- Empirical Formula: C16H14N2O3
- Molecular Weight: 282.29
- MDL number: MFCD00593702
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is CHEMBRDG-BB 5280909?
Description
ML-354 is an indole-based, proteinase-activated receptor 4 (PAR4) antagonist (IC50 = 140 nM) that exhibits 71-fold selectivity for PAR4 over PAR1 (IC50 = 10 μM) in isolated human platelets.
The Uses of CHEMBRDG-BB 5280909
ML-354 is a selective protease activated receptor 4 ( PAR-4) antagonist used for its antithrombotic effects.
Biochem/physiol Actions
ML354 is a potent and selective PAR4 (protease activated receptor-4) antagonist.
storage
Store at -20°C
References
[1]. wen, w., young, s., duvernay, m., schulte, m., nance, k., & melancon, b. et al. substituted indoles as selective protease activated receptor 4 (par-4) antagonists: discovery and sar of ml354. bioorganic & medicinal chemistry letters. 2014; 24(19): 4708-4713.
Properties of CHEMBRDG-BB 5280909
| Melting point: | 178-179 °C(Solv: 1,4-dioxane (123-91-1)) |
| Boiling point: | 544.0±50.0 °C(Predicted) |
| Density | 1.29±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | ≤2mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide |
| pka | 14.47±0.10(Predicted) |
| form | powder |
| color | white to beige |
Safety information for CHEMBRDG-BB 5280909
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral |
| Precautionary Statement Codes |
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for CHEMBRDG-BB 5280909
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