CH 55
- CAS NO.：110368-33-7
- Empirical Formula: C24H28O3
- Molecular Weight: 364.48
- MDL number: MFCD06798383
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is CH 55?
The Uses of CH 55
CH 55 is a synthetic analog of retinoic acid which is an effective inhibitor of angiogenesis. Retinoids and their analogs are also promising agents for cancer chemoprevention and therapy.
What are the applications of Application
CH 55 is a synthetic retinoid with high affinity at RAR-α and β
Definition
ChEBI: 4-[3-(3,5-ditert-butylphenyl)-3-oxoprop-1-enyl]benzoic acid is a member of chalcones.
Biological Activity
Highly potent synthetic retinoid that has high affinity for RAR- α and RAR- β receptors and low affinity for cellular retinoic acid binding protein (CRABP). Inhibits rabbit tracheal epithelial cell differentiation by inhibiting transglutaminase and increasing cholesterol sulfate (EC 50 values are 0.02 and 0.03 nM respectively). Induces differentiation of embryonic carcinoma F9 and melanoma S91 cells (EC 50 values are 0.26 and 0.5 nM respectively) and inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC 50 = 1 nM).
storage
Store at RT
Properties of CH 55
| Melting point: | 202-203.5 °C |
| Boiling point: | 509.5±50.0 °C(Predicted) |
| Density | 1.085±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | DMF: 25 mg/ml; DMSO: 25 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml; Ethanol: 5 mg/ml |
| form | A crystalline solid |
| pka | 4.09±0.10(Predicted) |
| color | White to light yellow |
| Stability: | Light Sensitive |
Safety information for CH 55
Computed Descriptors for CH 55
New Products
Tert-butyl bis(2-chloroethyl)carbamate 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid 1,1’-CARBONYLDIIMIDAZOLE DIETHYL AMINOMALONATE HYDROCHLORIDE R-2-BENZYLOXY PROPIONIC ACID 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) N-METHYL INDAZOLE-3-CARBOXYLIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 2-aminopropyl benzoate hydrochloride 1-(4-(aminomethyl)benzyl)urea hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
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