CH 55
- CAS NO.：110368-33-7
- Empirical Formula: C24H28O3
- Molecular Weight: 364.48
- MDL number: MFCD06798383
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is CH 55?
The Uses of CH 55
CH 55 is a synthetic analog of retinoic acid which is an effective inhibitor of angiogenesis. Retinoids and their analogs are also promising agents for cancer chemoprevention and therapy.
What are the applications of Application
CH 55 is a synthetic retinoid with high affinity at RAR-α and β
Definition
ChEBI: 4-[3-(3,5-ditert-butylphenyl)-3-oxoprop-1-enyl]benzoic acid is a member of chalcones.
Biological Activity
Highly potent synthetic retinoid that has high affinity for RAR- α and RAR- β receptors and low affinity for cellular retinoic acid binding protein (CRABP). Inhibits rabbit tracheal epithelial cell differentiation by inhibiting transglutaminase and increasing cholesterol sulfate (EC 50 values are 0.02 and 0.03 nM respectively). Induces differentiation of embryonic carcinoma F9 and melanoma S91 cells (EC 50 values are 0.26 and 0.5 nM respectively) and inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC 50 = 1 nM).
storage
Store at RT
Properties of CH 55
| Melting point: | 202-203.5 °C |
| Boiling point: | 509.5±50.0 °C(Predicted) |
| Density | 1.085±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | DMF: 25 mg/ml; DMSO: 25 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml; Ethanol: 5 mg/ml |
| form | A crystalline solid |
| pka | 4.09±0.10(Predicted) |
| color | White to light yellow |
| Stability: | Light Sensitive |
Safety information for CH 55
Computed Descriptors for CH 55
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Mefenamic Acid IP/BP/EP/USP Diclofenac Sodium IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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