CH 55

CAS NO.：110368-33-7
Empirical Formula: C24H28O3
Molecular Weight: 364.48
MDL number: MFCD06798383
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-30 20:13:01

What is CH 55?

The Uses of CH 55

CH 55 is a synthetic analog of retinoic acid which is an effective inhibitor of angiogenesis. Retinoids and their analogs are also promising agents for cancer chemoprevention and therapy.

What are the applications of Application

CH 55 is a synthetic retinoid with high affinity at RAR-α and β

Definition

ChEBI: 4-[3-(3,5-ditert-butylphenyl)-3-oxoprop-1-enyl]benzoic acid is a member of chalcones.

Biological Activity

Highly potent synthetic retinoid that has high affinity for RAR- α and RAR- β receptors and low affinity for cellular retinoic acid binding protein (CRABP). Inhibits rabbit tracheal epithelial cell differentiation by inhibiting transglutaminase and increasing cholesterol sulfate (EC 50 values are 0.02 and 0.03 nM respectively). Induces differentiation of embryonic carcinoma F9 and melanoma S91 cells (EC 50 values are 0.26 and 0.5 nM respectively) and inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC 50 = 1 nM).

storage

Store at RT

Properties of CH 55

Melting point:	202-203.5 °C
Boiling point:	509.5±50.0 °C(Predicted)
Density	1.085±0.06 g/cm3(Predicted)
storage temp.	Store at RT
solubility	DMF: 25 mg/ml; DMSO: 25 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml; Ethanol: 5 mg/ml
form	A crystalline solid
pka	4.09±0.10(Predicted)
color	White to light yellow
Stability:	Light Sensitive