Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listCGS 21680A

CGS 21680A

CGS 21680A Structural

What is CGS 21680A?

Chemical properties

White to Off-White Solid

The Uses of CGS 21680A

CGS 21680A is a potent, selective agonist of the adenosine A2A receptor (Ki = 11-46 nM). It is less effective at adenosine A1 and A3 receptors (Kis = 0.5-3.1 and 0.6-1 μM, respectively) and is without effect at adenosine A2B (Ki > 10 μM). CGS 21680A is commonly used to study the actions of the adenosine A2A receptor in cells and tissues.[Cayman Chemical]

The Uses of CGS 21680A

A selective A2A receptor agonist.

The Uses of CGS 21680A

Adenosine receptors are related to many diseases such as cardiovascular, autoimmune, and cancer. CGS 21680 is a potent and selective agonist of the adenosine A2A receptor, a member of G protein coupled receptor (1,2,3).

What are the applications of Application

CGS 21680 Hydrochloride is a selective Adenosine A2A-R agonist

Biological Activity

cgs 21680 hcl is a selective agonist of a2 adenosine receptor with ic50 value of 22nm [1].in rat striatal membranes, cgs 21680 potently prevents ligands from binding to a2 adenosine receptors with ic50 value of 22nm. in the binding assay, cgs 21680 shows no effect to other putative neurotransmitter/neuromodulator sites in brain membranes such as adrenergic, dopamine and serotonin. in the rat heart model, cgs 21680 is effective in increasing coronary flow with ec25 value of 2nm [1].

in vivo

the hydrochloride salt of cgs 21680 has potent efficacy to decrease blood pressure in the anesthetized normotensive rat with ed50 value of 9μg/kg. it also causes heart rate increasing up to 15%. besides that, cgs 21680 hcl significantly lower the blood pressure at dose of 10mg/kg in the spontaneously hypertensive rat. a transient elecation of heart rate is also observed at 30 min in the model [1].

storage

-20°C (desiccate)

References

[1] hutchison a j, webb r l, oei h h, et al. cgs 21680c, an a2 selective adenosine receptor agonist with preferential hypotensive activity. journal of pharmacology and experimental therapeutics, 1989, 251(1): 47-55.

Properties of CGS 21680A

Melting point: 204-206°C
storage temp.  Inert atmosphere,2-8°C
solubility  DMSO (Slightly, Heated), Methanol (Slightly, Heated)
form  Solid
color  White to Light Beige
Stability: Hygroscopic
CAS DataBase Reference 124431-80-7

Safety information for CGS 21680A

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for CGS 21680A

Related products of tetrahydrofuran

You may like

  • 7726-95-6 Bromine 99.5% AR (4 x 500ml) 99%
    7726-95-6 Bromine 99.5% AR (4 x 500ml) 99%
    7726-95-6
    View Details
  • Formamide 99%
    Formamide 99%
    75-12-7
    View Details
  • 376608-65-0 2-[[(3Ar,4S,6R,6As)-6-Aminotetrahydro-2,2-Dimethyl-4H-Cy 99%
    376608-65-0 2-[[(3Ar,4S,6R,6As)-6-Aminotetrahydro-2,2-Dimethyl-4H-Cy 99%
    376608-65-0
    View Details
  • 2, 4-Pyrimidinediamine 3-Oxide 99%
    2, 4-Pyrimidinediamine 3-Oxide 99%
    74638-76-9
    View Details
  • 111974-72-2 99%
    111974-72-2 99%
    111974-72-2
    View Details
  • 85-81-4 6-Methoxy-8-Nitroquinoline 99%
    85-81-4 6-Methoxy-8-Nitroquinoline 99%
    85-81-4
    View Details
  • 3-Bromo-4,5-Dihydro-1H-Benzo[B]Azepin-2(3H)-One 99%
    3-Bromo-4,5-Dihydro-1H-Benzo[B]Azepin-2(3H)-One 99%
    86499-96-9
    View Details
  • (−)-Dip-Chloride 85116-37-6 99%
    (−)-Dip-Chloride 85116-37-6 99%
    85116-37-6
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.