CGP 78608 HYDROCHLORIDE
- CAS NO.:206648-13-7
- Empirical Formula: C11H13BrN3O5P
- Molecular Weight: 378.12
- MDL number: MFCD06798371
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-07-14 17:48:26
What is CGP 78608 HYDROCHLORIDE?
The Uses of CGP 78608 HYDROCHLORIDE
CGP 78608 is a potent and selective NMDA antagonist.
Definition
ChEBI: CGP 78608 is a phosphonic acid in which the hydrogen attached to phosphorous is substituted by a 1-{[(7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl]amino}ethyl group. Potent and selective NMDA antagonist that acts through the glycine site (IC50 = 5 nM). Displays >500-fold selectivity over kainate and AMPA receptors (IC50 values are 2.7 and 3 muM respectively). Anticonvulsant in vivo following systemic administration. It has a role as a NMDA receptor antagonist and an anticonvulsant. It is a quinoxaline derivative, an organobromine compound, a secondary amino compound and a member of phosphonic acids. It contains a CGP 78608(1+).
Biological Activity
Potent and selective NMDA antagonist that acts through the glycine site (IC 50 = 5 nM). Displays > 500-fold selectivity over kainate and AMPA receptors (IC 50 values are 2.7 and 3 μ M respectively). Anticonvulsant in vivo following systemic administration. Also available as part of the NMDA Receptor - Glycine Site Tocriset™ .
Properties of CGP 78608 HYDROCHLORIDE
Density | 1.757±0.06 g/cm3(Predicted) |
storage temp. | Store at RT |
solubility | <41.46mg/ml in 2.2eq. NaOH |
pka | 0.66±0.10(Predicted) |
Safety information for CGP 78608 HYDROCHLORIDE
Computed Descriptors for CGP 78608 HYDROCHLORIDE
New Products
Tubulysin M Tubulysin I Tubulysin H 1-(1,1-Difluoroethyl)-2-fluorobenzene 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE tetrahydro-4-methyl-2H-pyran 2,2-Difluoropropylamine hydrochloride 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 2,2-Difluoropropanol (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Fuel shell 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Imeglimin Hydrochloride IH Calcium Sodium Phosphosilicate IH 3-fluoro-4- thiomorpholinoaniline (+/-)-2, 6-Diamino-4,5,6,7 -tetrahydro Benzothiazole Lubiprostone Magnesium Trisilicate Latanoprostene Bunod Flame Retardant Zinc Borate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acidRelated products of tetrahydrofuran
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