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HomeProduct name listCGP 42112

CGP 42112

Synonym(s):Nα-Nicotinoyl-Tyr-(Nα-Cbz-Arg)-Lys-His-Pro-Ile

CGP 42112 Structural

What is CGP 42112?

Definition

ChEBI: CGP-42112A is a hexapeptide consisting of L-tyrosine, L-lysine, L-histidine, L-proline and L-isoleucine amino acid residues coupled in sequence and in which the amino group of the L-tyrosyl residue is substituted by a (pyridin-3-ylcarbonyl)nitrilo group and in which the L-lysyl side chain amino group is substituted by a {N(2)-[(benzyloxy)carbonyl]-L-arginyl}nitrilo group. It is a potent angiotensin II receptor type 2 (AT2 receptor) agonist. It has a role as an angiotensin receptor agonist, a vasodilator agent, an antineoplastic agent, an anti-inflammatory agent and a neuroprotective agent. It is an oligopeptide, a benzyl ester and a pyridinecarboxamide.

Biochem/physiol Actions

Potent AT2 angiotensin II receptor agonist.

storage

Store at -20°C

Properties of CGP 42112

Density  1.39±0.1 g/cm3(Predicted)
storage temp.  -20°C
solubility  DMSO:350.0(Max Conc. mg/mL);332.64(Max Conc. mM)
pka 3.72±0.22(Predicted)
form  solid
color  white
Water Solubility  Soluble to 1 mg/ml in water
BRN  8184948

Safety information for CGP 42112

Computed Descriptors for CGP 42112

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