Cefmetazole sodium

CAS NO.：56796-39-5
Empirical Formula: C15H18N7NaO5S3
Molecular Weight: 495.52
MDL number: MFCD00214260
EINECS: 627-393-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-17 08:48:38

What is Cefmetazole sodium?

Chemical properties

White Solid

The Uses of Cefmetazole sodium

Cefmetazole sodium is used clinically in combination with Tanreqing for the treatment of Pulmonary infections like Senile Emphysema and other acute bacterial infections.

The Uses of Cefmetazole sodium

Semi-synthetic antibiotic derived from Cephamycin. Antibacterial

What are the applications of Application

Cefmetazole sodium salt is a cephalosporin antibiotic

Definition

ChEBI: An organic sodium salt that is the sodium salt of cefmetazole.

brand name

Zefazone (Pharmacia & Upjohn）.

Clinical Use

Cefmetazole (Zefazone) is a semisynthetic, third-generation,parenteral cephalosporin of the cephamycin group. Likeother cephamycins, the presence of the 7α-methoxyl groupconfers resistance to many β-lactamases. Cefmetazoleexhibits significantly higher potency against members ofthe Enterobacteriaceae family but lower activity againstBacteroides spp. than cefoxitin. It is highly active againstN. gonorrhoeae, including -lactamase–producing strains. Incommon with other cephamycins, cefmetazole is ineffectiveagainst indole-positive Proteus, Enterobacter, Providencia,Serratia, and Pseudomonas spp. Cefmetazole has the MTTmoiety associated with increased bleeding in certain highriskpatients. It has a plasma half-life of 1.1 hours.

Properties of Cefmetazole sodium

Melting point:	>130°C (dec.)
storage temp.	Inert atmosphere,2-8°C
solubility	H2O: soluble50mg/mL
form	powder
color	White to Off-White
Water Solubility	Soluble in water
Sensitive	Hygroscopic
Merck	14,1926
Stability:	Hygroscopic
CAS DataBase Reference	56796-39-5(CAS DataBase Reference)

Safety information for Cefmetazole sodium

Signal word	Danger
Pictogram(s)	Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H334:Sensitisation, respiratory H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.