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HomeProduct name listCD437

CD437

Synonym(s):6-(3-(1-Adamantyl)-4-hydroxyphenyl)-2-naphthalene carboxylic acid;6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid;AHPN;Apoptosis Activator VI, CD437/AHPN - CAS 125316-60-1 - Calbiochem

  • CAS NO.:125316-60-1
  • Empirical Formula: C27H26O3
  • Molecular Weight: 398.49
  • MDL number: MFCD03106506
  • EINECS: 200-258-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-01 18:09:03
CD437 Structural

What is CD437?

Chemical properties

Yellow Solid

The Uses of CD437

An intermediate in the preparation of Adapalene derivatives.

What are the applications of Application

CD 437 is A cell-permeable retinoid-related molecule tumor growth arrest and apoptosis inducer

Definition

ChEBI: A naphthoic acid that is 6-phenylnaphthylene-2-carboxyic acid in which the phenyl substituent has been substituted at positions 3 and 4 by adamant-1-yl and hydroxy groups, respectively. It acts as a selective agonist of retinoic acid receptor (RAR)g mma and induces cell cycle arrest and apoptosis in various cancer cells.

Biological Activity

Synthetic retinoid that is an RAR γ -selective agonist. Displays RAR γ -dependent and -independent effects on differentiation and apoptosis.

Biochem/physiol Actions

CD437 is a retinoic acid receptor (RAR)γ-selective agonist, γ-selective retinoid; potent inducer of apoptosis.

storage

Store at -20°C

Properties of CD437

Melting point: 271.6-276 °C
Boiling point: 595.0±50.0 °C(Predicted)
Density  1.290
storage temp.  -20°C
solubility  DMSO: 26 mg/mL
form  solid
pka 4.17±0.30(Predicted)
color  yellow

Safety information for CD437

Computed Descriptors for CD437

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