CD437
Synonym(s):6-(3-(1-Adamantyl)-4-hydroxyphenyl)-2-naphthalene carboxylic acid;6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid;AHPN;Apoptosis Activator VI, CD437/AHPN - CAS 125316-60-1 - Calbiochem
- CAS NO.：125316-60-1
- Empirical Formula: C27H26O3
- Molecular Weight: 398.49
- MDL number: MFCD03106506
- EINECS: 200-258-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is CD437?
Chemical properties
Yellow Solid
The Uses of CD437
An intermediate in the preparation of Adapalene derivatives.
What are the applications of Application
CD 437 is A cell-permeable retinoid-related molecule tumor growth arrest and apoptosis inducer
Definition
ChEBI: A naphthoic acid that is 6-phenylnaphthylene-2-carboxyic acid in which the phenyl substituent has been substituted at positions 3 and 4 by adamant-1-yl and hydroxy groups, respectively. It acts as a selective agonist of retinoic acid receptor (RAR)g mma and induces cell cycle arrest and apoptosis in various cancer cells.
Biological Activity
Synthetic retinoid that is an RAR γ -selective agonist. Displays RAR γ -dependent and -independent effects on differentiation and apoptosis.
Biochem/physiol Actions
CD437 is a retinoic acid receptor (RAR)γ-selective agonist, γ-selective retinoid; potent inducer of apoptosis.
storage
Store at -20°C
Properties of CD437
| Melting point: | 271.6-276 °C |
| Boiling point: | 595.0±50.0 °C(Predicted) |
| Density | 1.290 |
| storage temp. | -20°C |
| solubility | DMSO: 26 mg/mL |
| form | solid |
| pka | 4.17±0.30(Predicted) |
| color | yellow |
Safety information for CD437
Computed Descriptors for CD437
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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