125316-60-1
Product Name:
CD437
Formula:
C27H26O3
Synonyms:
6-(3-(1-Adamantyl)-4-hydroxyphenyl)-2-naphthalene carboxylic acid;6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid;AHPN;Apoptosis Activator VI, CD437/AHPN - CAS 125316-60-1 - Calbiochem
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COMPUTED DESCRIPTORS
| Molecular Weight | 398.5 g/mol |
|---|---|
| XLogP3 | 7.4 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 3 |
| Exact Mass | 398.18819469 g/mol |
| Monoisotopic Mass | 398.18819469 g/mol |
| Topological Polar Surface Area | 57.5 Ų |
| Heavy Atom Count | 30 |
| Formal Charge | 0 |
| Complexity | 630 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
CD437 is a naphthoic acid that is 6-phenylnaphthylene-2-carboxyic acid in which the phenyl substituent has been substituted at positions 3 and 4 by adamant-1-yl and hydroxy groups, respectively. It acts as a selective agonist of retinoic acid receptor (RAR)gamma and induces cell cycle arrest and apoptosis in various cancer cells. It has a role as an apoptosis inducer and a retinoic acid receptor gamma agonist. It is a member of adamantanes, a monocarboxylic acid, a naphthoic acid and a member of phenols.