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CAY10568

CAY10568 Structural

What is CAY10568?

Description

Most local anesthetics act by abolishing voltage gated sodium channel currents indiscriminately in all populations of neurons. Selective analgesia through TRPV1-mediated entry of a cationic lidocaine derivative, QX314, was recently reported.1 CAY10568 is a physically smaller, less hydrophobic version of QX314 designed to be even more permeable to TRPV1 ion channel when activated by agonists such as capsaicin and N-oleoyl dopamine. CAY10568 when given in combination with suitable TRPV1 agonists should produce selective blockade of the pain response while leaving motor, touch, and proprioception intact.

References

1. Binshtok, A.M., Bean, B.P., and Woolf, C.J. Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers Nature 449,607-610(2007).

Properties of CAY10568

storage temp.  Store at -20°C
solubility  DMF: 5 mg/ml; DMSO: 3 mg/ml; PBS (pH 7.2): 0.5 mg/ml
form  A crystalline solid

Safety information for CAY10568

Computed Descriptors for CAY10568

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