CARUMONAM
- CAS NO.:87638-04-8
- Empirical Formula: C12H14N6O10S2
- Molecular Weight: 466.4
- MDL number: MFCD00871292
- SAFETY DATA SHEET (SDS)
- Update Date: 2022-12-21 16:56:50
What is CARUMONAM?
Description
Canunonam is an injectable antibiotic, the second monobactam ever developed (the first being Squibb’s aztreonam). It is highly active against Gram negative bacteria, particularly pseudomom, and is reportedly effective in the treatment of pneumonia, cystitis, peritonitis and secondary infections.
Originator
Takeda (Japan)
Definition
ChEBI: An N-sulfonated monobactam antibiotic.
brand name
Amasulin
Antimicrobial activity
A synthetic monobactam with activity against common
pathogenic organisms similar to that of aztreonam. It is resistant
to hydrolysis by the common plasmid and chromosomal
β-lactamases, but it can be hydrolyzed by ESBLs.
It is administered intravenously, achieving a concentration
of c. 78 mg/L after a 20-min infusion of 1 g. The plasma halflife
is 1.7 h and the plasma protein binding 18–28%.
Carumonam is almost entirely eliminated in the glomerular
filtrate, probenecid having no effect on excretion; 96%
of labeled compound is found in the urine, with 3% in the
feces. Between 68% and 91% of the dose appears in the urine
within 24 h.
Side effects and clinical use are similar to those of
aztreonam.
Properties of CARUMONAM
alpha | D26 -45° (c = 1 in DMSO) |
Density | 2.13±0.1 g/cm3(Predicted) |
pka | -0.43±0.60(Predicted) |
Safety information for CARUMONAM
Computed Descriptors for CARUMONAM
Related products of tetrahydrofuran
You may like
-
LEAD AAS SOLUTION 99%View Details
-
ZIRCONIUM AAS SOLUTION 99%View Details
-
FUCHSIN BASIC 0.1% SOLUTION 99%View Details
-
1 10-PHENANTHROLIN HYDROCHLORIDE 99%View Details
-
ERDMANS REAGENT (FOR PROTEIN TEST) 99%View Details
-
OXALIC ACID SOLUTION 0.1 N 99%View Details
-
ALKALINE COPPER SOLUTION 99%View Details
-
A-AMYLASE (DIASTASE) 99%View Details