Cariprazine-d6
- CAS NO.:1308278-67-2
- Empirical Formula: C21H32Cl2N4O
- Molecular Weight: 427.41
- Update Date: 2024-10-28 16:48:35
What is Cariprazine-d6?
Description
Cariprazine-d6 is intended for use as an internal standard for the quantification of cariprazine by GC- or LC-MS. Cariprazine is an atypical antipsychotic.1 It binds to dopamine D2L, D2S, and D3 receptors, the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, and 5-HT2B, and histamine H1 and sigma-1 (σ1) receptors (Kis = 0.085-23.44 nM).2 Cariprazine is an antagonist of dopamine D2 and D3 receptors (Kbs = 0.759 and 0.316 nM, respectively, in dopamine-induced [35S]GTPγS binding assays). It is also a partial agonist at these receptors, stimulating inositol phosphate production in murine A9 cells expressing human D2L receptors (EC50 = 3.16 nM) and inhibiting forskolin-induced cAMP accumulation in CHO cells expressing human D3 receptors (EC50 = 2.63 nM). Cariprazine inhibits amphetamine-induced hyperactivity and the conditioned avoidance response in rats (ED50s = 0.12 and 0.84 mg/kg, respectively).3 It also inhibits scopolamine-induced learning deficits in a water labyrinth learning test in rats when administered at doses ranging from 0.02 to 0.08 mg/kg. Formulations containing cariprazine have been used in the treatment of schizophrenia, as well as manic, depressive, or mixed episodes associated with bipolar I disorder.
References
1. Mészáros, G.P., Agai-Csongor, E., and Kapás, M. Sensitive LC-
2. Kiss, B., Horváth, A., Némethy, Z., et al. Cariprazine (RGH-
3. Gyertyán, I., Kiss, B., Sághy, K., et al. Cariprazine (RGH-
Properties of Cariprazine-d6
storage temp. | Store at -20°C |
solubility | DMSO: soluble |
form | A solid |
color | White to off-white |
Safety information for Cariprazine-d6
Computed Descriptors for Cariprazine-d6
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