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HomeProduct name listCARIPORIDE

CARIPORIDE

Synonym(s):HOE-642;N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)-benzamide;N-(Diaminomethylene)-4-isopropyl-3-(methylsulfonyl)benzamide

  • CAS NO.:159138-80-4
  • Empirical Formula: C12H17N3O3S
  • Molecular Weight: 283.35
  • MDL number: MFCD00864683
  • EINECS: 1592732-453-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-01 18:44:47
CARIPORIDE Structural

What is CARIPORIDE?

The Uses of CARIPORIDE

Cariporide is an Na+/H+ exchange inhibitor that functions to improve cellular integrity following events of cardiac ischemia and reperfusion (most commonly seen in non-heart beating donor organs). Cariporide is also used to prevent heart attacks in high-risk ischemic patients.

The Uses of CARIPORIDE

Reduction of death and nonfatal myocardial infarction in patients undergoing CABG surgery.

What are the applications of Application

Cariporide is an NHE-1 inhibitor that blocks apoptosis in cardiac muscle cells

Biological Activity

na–h exchange (nhe) represents an important mechanism for mediating such injury. nhe represents an important mechanism for the development of myocardial ischemic and reperfusion injury and inhibitors have been consistently shown to protect the ischemic and reperfused heart by correcting the ionic imbalance associated with this form of pathological insult. cariporide is a potent nhe inhibitor.

Biochem/physiol Actions

Cariporide is a selective inhibitor of the Na+/H+ exchanger subtype 1 (NHE-1), also known as the Na+/H+ antiporter. Cariporide has shown cardioprotective and antiarrhythmic effects, and has recently been investigated for anticancer activity.

in vitro

cariporide concentration dependently inhibited the amiloride sensitive sodium influx in rabbit erythrocytes, reduced the swelling of human platelets caused by intracellular acidification, and delayed ph recovery in rat cardiomyocytes [1].

in vivo

in anaesthetised rats undergoing coronary artery ligation intravenous and oral pretreatment with cariporide caused a dose dependent reduction or a complete prevention of ventricular premature beats, ventricular fibrillation, and ventricular tachycardia. the compound was well tolerated and neutral to circulatory variables [1].

storage

Store at +4°C

Properties of CARIPORIDE

Melting point: 90-94° (dec)
Density  1.34
storage temp.  2-8°C
solubility  insoluble in H2O; ≥12.05 mg/mL in DMSO; ≥2.675 mg/mL in EtOH with gentle warming and ultrasonic
form  powder
color  white to beige

Safety information for CARIPORIDE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for CARIPORIDE

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