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HomeProduct name listCALPAIN INHIBITOR II

CALPAIN INHIBITOR II

Synonym(s):ALLM - CAS 110115-07-6 - Calbiochem;Calpain Inhibitor II;N-Acetyl-L-leucyl-L-leucyl-L-methioninal

CALPAIN INHIBITOR II Structural

What is CALPAIN INHIBITOR II?

Chemical properties

white to off-white powder

The Uses of CALPAIN INHIBITOR II

Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons.

Definition

ChEBI: N-Acetylleucyl-leucyl-methioninal is a peptide.

General Description

A cell-permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 0.6 nM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Also prevents nitric oxide produced by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.

Biochem/physiol Actions

Calpain is a cysteine protease expressed in the nervous system. Calpain exhibits a calcium-dependent enzyme activity. In mice models, inhibition of calpain prevents leukocyte infiltration induced by angiotensin II and also attenuates prevascular inflammation.

Properties of CALPAIN INHIBITOR II

Boiling point: 676.5±55.0 °C(Predicted)
Density  1.076±0.06 g/cm3(Predicted)
storage temp.  -20°C
solubility  ethanol: 20 mg/mL
form  powder
pka 13.32±0.46(Predicted)
color  white
CAS DataBase Reference 110115-07-6(CAS DataBase Reference)

Safety information for CALPAIN INHIBITOR II

Computed Descriptors for CALPAIN INHIBITOR II

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