CALPAIN INHIBITOR II
Synonym(s):ALLM - CAS 110115-07-6 - Calbiochem;Calpain Inhibitor II;N-Acetyl-L -leucyl-L -leucyl-L -methioninal
- CAS NO.:110115-07-6
- Empirical Formula: C19H35N3O4S
- Molecular Weight: 401.56
- MDL number: MFCD00065506
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:16
What is CALPAIN INHIBITOR II?
Chemical properties
white to off-white powder
The Uses of CALPAIN INHIBITOR II
Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons.
Definition
ChEBI: N-Acetylleucyl-leucyl-methioninal is a peptide.
General Description
A cell-permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 0.6 nM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Also prevents nitric oxide produced by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.
Biochem/physiol Actions
Calpain is a cysteine protease expressed in the nervous system. Calpain exhibits a calcium-dependent enzyme activity. In mice models, inhibition of calpain prevents leukocyte infiltration induced by angiotensin II and also attenuates prevascular inflammation.
Properties of CALPAIN INHIBITOR II
Boiling point: | 676.5±55.0 °C(Predicted) |
Density | 1.076±0.06 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | ethanol: 20 mg/mL |
form | powder |
pka | 13.32±0.46(Predicted) |
color | white |
CAS DataBase Reference | 110115-07-6(CAS DataBase Reference) |
Safety information for CALPAIN INHIBITOR II
Computed Descriptors for CALPAIN INHIBITOR II
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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