CALPAIN INHIBITOR II
Synonym(s):ALLM - CAS 110115-07-6 - Calbiochem;Calpain Inhibitor II;N-Acetyl-L -leucyl-L -leucyl-L -methioninal
- CAS NO.:110115-07-6
- Empirical Formula: C19H35N3O4S
- Molecular Weight: 401.56
- MDL number: MFCD00065506
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:16
What is CALPAIN INHIBITOR II?
Chemical properties
white to off-white powder
The Uses of CALPAIN INHIBITOR II
Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons.
Definition
ChEBI: N-Acetylleucyl-leucyl-methioninal is a peptide.
General Description
A cell-permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 0.6 nM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Also prevents nitric oxide produced by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.
Biochem/physiol Actions
Calpain is a cysteine protease expressed in the nervous system. Calpain exhibits a calcium-dependent enzyme activity. In mice models, inhibition of calpain prevents leukocyte infiltration induced by angiotensin II and also attenuates prevascular inflammation.
Properties of CALPAIN INHIBITOR II
Boiling point: | 676.5±55.0 °C(Predicted) |
Density | 1.076±0.06 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | ethanol: 20 mg/mL |
form | powder |
pka | 13.32±0.46(Predicted) |
color | white |
CAS DataBase Reference | 110115-07-6(CAS DataBase Reference) |
Safety information for CALPAIN INHIBITOR II
Computed Descriptors for CALPAIN INHIBITOR II
New Products
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