CALMIDAZOLIUM CHLORIDE

Synonym(s):1-[bis(4-Chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-(2,4-dichlorobenzyloxy)ethyl]-1H-imidazolium chloride;1-[Bis(4-chlorophenyl)methyl]-3-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]imidazolium chloride;Poly-p-methoxyphenethylmethylamine;

CAS NO.：57265-65-3
Empirical Formula: C31H23Cl7N2O
Molecular Weight: 687.69
MDL number: MFCD00077679
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 15:53:33

What is CALMIDAZOLIUM CHLORIDE?

Chemical properties

white to off-white powder

The Uses of CALMIDAZOLIUM CHLORIDE

Calmidazolium chloride is a small molecule CaM antagonist and calcium channel protein inhibitor. Calmidazolium chloride demonstrates noncompetitive inhibition of platelet and sarcoplasmic reticulum Ca2+-ATPase activity and shows inhibition of Ca2+?transport activity in platelet microsomes. In HeLa cells, calmidazolium chloride stimulates a mechanism of cellular Ca2+?influx distinct from store-operated Ca2+?entry and unaccompanied by Ca2+?store depletion, mobilizing stores and evoking a Ca2+?signal through activation of phospholipase C. Calmidazolium chloride is described to inhibit constitutive nitric oxide synthase (NOS) activity without affecting inducible NOS in rat aorta. The dependence upon calmodulin of neuronal NOS (nNOS) in neuroblastoma N1E-115 cells was probed with calmidazolium chloride, where it was demonstrated to increase cGMP levels indirectly indicating an increase in NO output by nNOS. Calmidazolium chloride is also described to inhibit the activity of calmodulin N-methyltransferase.

What are the applications of Application

Calmidazolium chloride is a CaM and calcium channel protein inhbitor

General Description

Compound 48/80, is the condensation product of N-methyl p-methoxyphenethylamine and formaldehyde.

Biological Activity

Calmodulin antagonist. Inhibits calmodulin-dependent phosphodiesterase and Ca 2+ -transporting ATPase with IC 50 values of 0.15 and 0.35 μ M respectively. Also causes elevation of intracellular calcium in HL-60 cells, independent of calmodulin inhibition.

Biochem/physiol Actions

Inhibitor of calmodulin-regulated enzymes. It is also believed to directly block calcium channels in smooth muscle cells.

storage

+4°C

Properties of CALMIDAZOLIUM CHLORIDE

Melting point:	172-176 °C
storage temp.	2-8°C
solubility	Soluble to 100 mM in DMSO and to 100 mM in ethanol
form	solid
color	white
Water Solubility	Soluble in dimethyl sulfoxide, ethanol. methanol, chloroform, and propylene glycol. Insoluble in water.
BRN	6470244

Safety information for CALMIDAZOLIUM CHLORIDE

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P403+P233:Store in a well-ventilated place. Keep container tightly closed.