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HomeProduct name listCalcipotriol Monohydrate

Calcipotriol Monohydrate

  • CAS NO.:147657-22-5
  • Empirical Formula: C27H42O4
  • Molecular Weight: 430.63
  • MDL number: MFCD10567086
  • EINECS: 689-035-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
Calcipotriol Monohydrate Structural

What is Calcipotriol Monohydrate?

Description

Calcipotriol (hydrate) is a low-calcemic vitamin D receptor (VDR) agonist. Calcipotriol (hydrate) is about 200 times less potent in its effects on calcium metabolism than vitamin D (1,25[OH]D3). Binding of calcipotriol (hydrate) to the VDR increases AP-1, a transcription factor important for keratinocyte differentiation, and reduces expression of JunB protein, a transcriptional activator in the inflammatory response. Calcipotriol (hydrate) also induces expression of thymic stromal lymphopoietin, which triggers T-cell differentiation in keratinocytes.

Chemical properties

White or almost white, crystalline powder.

The Uses of Calcipotriol Monohydrate

Vitamin D analogue.

Definition

ChEBI: A hydrate that is the monohydrate form of calcipotriol. It is used in combination with betamethasone dipropionate, a corticosteroid, for the topical treatment of plaque psoriasis in adult patients.

Properties of Calcipotriol Monohydrate

storage temp.  4°C, protect from light, stored under nitrogen,unstable in solution, ready to use.
solubility  Practically insoluble in water, freely soluble in ethanol (96 per cent), slightly soluble in methylene chloride.
form  Powder
color  White to off-white
Stability: Hygroscopic, Light sensitive

Safety information for Calcipotriol Monohydrate

Computed Descriptors for Calcipotriol Monohydrate

InChIKey XBKHACNRWFKJNC-IZXATKCONA-N
SMILES C[C@]12CCC/C(=C\C=C3\C[C@@H](O)C[C@H](O)C\3=C)/[C@]1([H])CC[C@]2([H])[C@H](C)/C=C/[C@H](C1CC1)O.O |&1:1,10,13,17,21,23,27,r|

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