Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listCA-074

CA-074

Synonym(s):(L-3-trans-(Propylcarbamyl)oxirane-2-carbonyl)-L-isoleucyl-L-proline

  • CAS NO.:134448-10-5
  • Empirical Formula: C18H29N3O6
  • Molecular Weight: 383.44
  • MDL number: MFCD00797531
  • EINECS: 200-258-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-07-02 08:55:16
CA-074 Structural

What is CA-074?

The Uses of CA-074

CA-074 is a potent and specific inhibitor of cathepsin B in vitro.

The Uses of CA-074

Inhibitor of Cathepsin B.

What are the applications of Application

CA-074 is a potent and specific inhibitor of cathepsin B in vitro

Biological Activity

ca-074, a specific cathepsin b inhibitor, also abolished the neurotoxic effects caused by abeta42-activated bv2 cell [1]. co-treatment of cultures with the cathepsin b inhibitors ca-074 or z-fa-fmk suppressed the cytostatic effects of tpa and activation of pro-upa [2]. administration of ca-074 suppresses the response to exogenous antigens, such as hepatitis b virus antigen, ovalbumin and leishmania major antigen, and induces switching of the helper t cell responses from th-2 to th-1 of cd4+ t cell, thereby down regulating the production of ige and igg1 [3]. pharmacological inhibition of cat b in catb(+/+) mice with l-3-trans-(propylcarbamoyl)oxirane-2-carbonyl-lisoleucyl-l-proline (ca-074 me) also reduced tnf-alpha-induced liver damage. [4] administration of cathepsin b inhibitors, e-64, ca-074 and vitamin b6, caused the strong suppression of the th-2 type immune responses .inhibitor of cathepsin b (ki = 2-5 nm). displays selectivity over cathepsins h and l (ki = 40-200 μm). shown to reduce bone metastasis in a 4t1.2 breast cancer model.

storage

Store at -20°C

References

1. identification of cathepsin b as a mediator of neuronal death induced by abeta-activated microglial cells using a functional genomics approach. gan, l., ye, s., chu, a., anton, k., yi, s., vincent, v.a., von schack, d., chin, d., murray, j., lohr, s., patthy, l., gonzalez-zulueta, m., nikolich, k., urfer, r. j. biol. chem. (2004) 2. phorbol ester activation of a proteolytic cascade capable of activating latent transforming growth factor-betal a process initiated by the exocytosis of cathepsin b. guo, m., mathieu, p.a., linebaugh, b., sloane, b.f., reiners, j.j. j. biol. chem. (2002) 3. insights into the roles of cathepsins in antigen processing and presentation revealed by specific inhibitors. katunuma, n., matsunaga, y., himeno, k., hayashi, y. biol. chem. (2003) 4. cathepsin b knockout mice are resistant to tumor necrosis factor-alpha-mediated hepatocyte apoptosis and liver injury: implications for therapeutic applications. guicciardi, m.e., miyoshi, h., bronk, s.f., gores, g.j. am. j. pathol. (2001)

Properties of CA-074

Boiling point: 728.9±60.0 °C(Predicted)
Density  1.267±0.06 g/cm3(Predicted)
storage temp.  -20°C
solubility  Soluble in methanol at 1mg/ml. Also soluble in DMSO or ethanol.
form  solid
pka 3.43±0.20(Predicted)
color  White to yellow

Safety information for CA-074

Computed Descriptors for CA-074

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.