C8 CERAMIDE
- CAS NO.:74713-59-0
- Empirical Formula: C26H51NO3
- Molecular Weight: 425.69
- MDL number: MFCD00236496
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is C8 CERAMIDE?
Description
C8-ceramide (74713-59-0) is a cell permeable ceramide analog. Stimulates ceramide-activated protein kinase.1?Induces apoptosis.2?Reported to inhibit apoptosis and gap junction intercellular communication (GJIC) in rat liver epithelial cells.3?C8-ceramide induces the secretion of brain-derived neurotrophic factor (BDNF) from microglia?in vitro.4
Chemical properties
Off White Powder
The Uses of C8 CERAMIDE
A biologically active, cell permeable, but nonphysiologic ceramide analog. It induces phosphorylation on Thr-669 in A-431 cells by stimulation of ceramide-activated protein kinase. It stimulates IL-2 secretion and induces apoptosis
The Uses of C8 CERAMIDE
C-8 Ceramide is a ceramide analog.
What are the applications of Application
C-8 Ceramide is a ceramide analog
Definition
ChEBI: N-octanoylsphingosine is an N-acylsphingosine in which the ceramide N-acyl group is specified as octanoyl. It is functionally related to an octanoic acid.
References
1) Mathias?et al. (1991) Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha; Proc. Natl. Acad. Sci. USA,?88?109 2) Jarvis?et al. (1993)?Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway; Proc. Natl. Acad. Sci. USA?91?73 3) Upham?et al. (2003),?Differential roles of 2,6 and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesis; Cancer Lett.,?191?27 4) Nakajima?et al. (2002),?Ceramide activates microglia to enhance the production/secretion of brain-derived neurotrophic factor (BDNF) without induction of deleterious factors in vitro; J. Neurochem.,?80?697
Properties of C8 CERAMIDE
Melting point: | 68-70°C |
Boiling point: | 541.37°C (rough estimate) |
Density | 0.9974 (rough estimate) |
refractive index | 1.6000 (estimate) |
storage temp. | −20°C |
solubility | DMSO or ethanol: soluble |
form | waxy solid |
color | White |
Stability: | Temperature Sensitive |
CAS DataBase Reference | 74713-59-0(CAS DataBase Reference) |
Safety information for C8 CERAMIDE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for C8 CERAMIDE
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