bupicomide
- CAS NO.:22632-06-0
- Empirical Formula: C10H14N2O
- Molecular Weight: 178.234
- MDL number: MFCD00865843
- EINECS: 2451431
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:36
What is bupicomide ?
Originator
Bupicomide,ZYF Pharm Chemical
The Uses of bupicomide
Antihypertensive.
Definition
ChEBI: Bupicomide is an organothiophosphorus compound and a phosphoramide.
Manufacturing Process
3-n-Butyl-6-methyl-3,4-dihydro-1,2-pyran was obtained and isolated from the
reaction mixture by fractional distillation in vacuum to separate a by-product
formed by cyclodimerisation of methyl vinylketone. The yield of the3-n-butyl-
6-methyl-3,4-dihydro-1,2-pyran was 47% (boiling point 106-107°C.
The saponification of the 3-n-butyl-6-methyl-3,4-dihydro-1,2-pyran was
accomplished by heating for 0.5 h in a mixture with acetic acid. The 1-methyl-
4-n-butyl-1,5-dicarbonyl acid formed not isolated from the reaction mixture
was added to hydroxylamine. The reaction with hydroxylamine was carried out
by gradual addition of acetic acid solution of 1,5-dicarbonyl compound to the
stirring refluxing suspension of hydroxylamine in glacial acetic acid. By usual
treatment was fractionned in vacuum to yield 37.5% of 2-methyl-5-nbutylpyridine,
boiling point 105°C.
The 2-methyl-5-n-butylpyridine was oxidated by selenium dioxide in pyridine
to 5-n-butyl-2-pyridine carboxylic (fusarinic) acid, melting point 100-101°C.
25.0 g of the 5-n-butyl-2-pyridine carboxylic (fusarinic) acid and 25 ml of
thionyl chloride were mixed; after all of the acid is dissolved, concentrate (in
vacuo) the mixture and take up the mixture in 500 ml of anhydrous benzene;
with cooling add the mixture to a solution of excess ammonia in 1 l of
benzene, concentrate (in vacuo) the resulting mixture; add water and
potassium carbonate and extract the amide with ether; dry and concentrate
the ether extract and 5-n-butyl-2-pyridine carboxamide was obtained
(recrystallize from acetonitrile).
Therapeutic Function
Antihypertensive
Properties of bupicomide
Melting point: | 128 °C |
Boiling point: | 338.6±30.0 °C(Predicted) |
Density | 1.066±0.06 g/cm3(Predicted) |
pka | 15.28±0.50(Predicted) |
Safety information for bupicomide
Computed Descriptors for bupicomide
New Products
6-Bromo 2-Iodo Indole Fosfomycin EP impurity D Rimegepant Impurity 3 Ivermectin EP Impurity B Tubulysin M Tubulysin C Tubulysin I Tubulysin H Potassium HMDS (1.0 M in THF) Calcium Sodium Phosphosilicate IH (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Imeglimin Hydrochloride IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Fuel shell 2-(2,4-Dibutoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 3,3,6,6-Tetramethylcyclohexane-1,2-dione 2-Chloro-3-(chloromethyl)pyridine 2-(3,5-Di-tert-butylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 3,6-Bis(4-bromophenyl)pyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione 3-(4-bromo-1H-pyrazol-1-yl)-N,N-dimethylpropanamide 6-bromo-4-methyl-2-propyl-1H-1,3-benzodiazole 6-bromopyridazin-3-amineRelated products of tetrahydrofuran
You may like
-
Bupicomide >95% CAS 22632-06-0View Details
22632-06-0 -
3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dioneView Details
952145-70-9 -
1262243-12-8View Details
1262243-12-8 -
65195-56-4View Details
65195-56-4 -
Rimegepant Impurity 3View Details
-
Sidchem 730View Details
-
Sidchem BT 20View Details
-
1572177-89-9View Details
1572177-89-9