Brompheniramine

Absorption

Antihistamines are well absorbed from the gastrointestinal tract after oral administration.

Toxicity

Oral, rat: LD50 = 318 mg/kg. Signs of overdose include fast or irregular heartbeat, mental or mood changes, tightness in the chest, and unusual tiredness or weakness.

The Uses of Brompheniramine

Brompheniramine is also used for allergy symptoms, rhinitis, and dermatitis. Its activity is approximately the same as that of chlorpheniramine. Synonyms of this drug are dimetane, brombey, spentan, veltane, and others.

The Uses of Brompheniramine

antidepressant

Indications

For the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing.

What are the applications of Application

Brompheniramine is a reuptake inhibitor of seratonin

Background

Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria.

Definition

ChEBI: Pheniramine in which the hydrogen at position 4 of the phenyl substituent is substituted by bromine. A histamine H1 receptor antagonist, brompheniramine is used (commonly as its maleate salt) for the symptomatic relief of allergic cond tions, including rhinitis and conjunctivitis.

brand name

Dimetane (Wyeth).

Pharmacokinetics

Brompheniramine is an antihistaminergic medication of the propylamine class. It is a first-generation antihistamine. In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Brompheniramine is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.

Metabolism

Hepatic (cytochrome P-450 system), some renal.