Bromo-PEG1-Acid
- CAS NO.:1393330-33-0
- Empirical Formula: C5H9BrO3
- Molecular Weight: 197.03
- MDL number: MFCD22574802
- Update Date: 2024-10-23 13:36:13
What is Bromo-PEG1-Acid?
Description
Bromo-PEG1-acid is a PEG linker containing a bromide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
The Uses of Bromo-PEG1-Acid
Bromo-PEG1-acid is a heterobifunctional, PEGylated crosslinker featuring a bromo group at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. Bromo-PEG1-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.
Properties of Bromo-PEG1-Acid
storage temp. | -20°C |
solubility | DMSO : 100 mg/mL (507.54 mM; Need ultrasonic) |
form | Liquid |
color | Colorless to light yellow |
Safety information for Bromo-PEG1-Acid
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Bromo-PEG1-Acid
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