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HomeProduct name listBromo-PEG1-Acid

Bromo-PEG1-Acid

  • CAS NO.:1393330-33-0
  • Empirical Formula: C5H9BrO3
  • Molecular Weight: 197.03
  • MDL number: MFCD22574802
  • Update Date: 2024-10-23 13:36:13
Bromo-PEG1-Acid Structural

What is Bromo-PEG1-Acid?

Description

Bromo-PEG1-acid is a PEG linker containing a bromide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

The Uses of Bromo-PEG1-Acid

Bromo-PEG1-acid is a heterobifunctional, PEGylated crosslinker featuring a bromo group at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. Bromo-PEG1-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.

Properties of Bromo-PEG1-Acid

storage temp.  -20°C
solubility  DMSO : 100 mg/mL (507.54 mM; Need ultrasonic)
form  Liquid
color  Colorless to light yellow

Safety information for Bromo-PEG1-Acid

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Bromo-PEG1-Acid

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