Brimonidine Tartrate
Synonym(s):Brimonidine tartrate
- CAS NO.：70359-46-5
- Empirical Formula: C15H16BrN5O6
- Molecular Weight: 442.22
- MDL number: MFCD07773072
- EINECS: 629-848-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-26 17:21:34
What is Brimonidine Tartrate?
Description
Brimonidine is an agonist of α2-adrenergic receptors (α2-ARs; Kis = 2.7, 52, and 44 nM for α2A, α2B, and α2C-ARs, respectively, in CHO cells). It is selective for α2-ARs over α1-ARs (Ki = 1,800 nM in human brain). Brimonidine lowers intraocular pressure in DBA/2J mice, a model of glaucoma, to control levels when applied topically to the eye as a 0.1% solution. It also inhibits glutamate release, prevents upregulation of NMDA receptors containing NR1 and NR2A subunits, and protects rat retinal ganglion cells against glutamate excitotoxicity in a rat model of retinal ischemia when administered at a dose of 1 mg/kg per day. Formulations containing brimonidine have been used in the treatment of open-angle glaucoma and ocular hypertension.
The Uses of Brimonidine Tartrate
It is an a 2 receptor agonist. It is a drug used to treat glaucoma. It acts via decreasing aqueous humor synthesis
What are the applications of Application
Brimonidine Tartrate is an α-2 receptor agonist
Properties of Brimonidine Tartrate
| Melting point: | 207-208°C (dec.) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| form | neat |
Safety information for Brimonidine Tartrate
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Brimonidine Tartrate
| InChIKey | QZHBYNSSDLTCRG-WUUYCOTASA-N |
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