Brimonidine Tartrate

Synonym(s):Brimonidine tartrate

CAS NO.：70359-46-5
Empirical Formula: C15H16BrN5O6
Molecular Weight: 442.22
MDL number: MFCD07773072
EINECS: 629-848-5
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-29 16:50:29

What is Brimonidine Tartrate?

Description

Brimonidine is an agonist of α₂-adrenergic receptors (α₂-ARs; K_is = 2.7, 52, and 44 nM for α_2A, α_2B, and α_2C-ARs, respectively, in CHO cells). It is selective for α₂-ARs over α₁-ARs (K_i = 1,800 nM in human brain). Brimonidine lowers intraocular pressure in DBA/2J mice, a model of glaucoma, to control levels when applied topically to the eye as a 0.1% solution. It also inhibits glutamate release, prevents upregulation of NMDA receptors containing NR1 and NR2A subunits, and protects rat retinal ganglion cells against glutamate excitotoxicity in a rat model of retinal ischemia when administered at a dose of 1 mg/kg per day. Formulations containing brimonidine have been used in the treatment of open-angle glaucoma and ocular hypertension.

Chemical properties

Off-White Crystalline Solid

The Uses of Brimonidine Tartrate

It is an a 2 receptor agonist. It is a drug used to treat glaucoma. It acts via decreasing aqueous humor synthesis

The Uses of Brimonidine Tartrate

It is an α2 receptor agonist. It is a drug used to treat glaucoma.

The Uses of Brimonidine Tartrate

Antitussive

The Uses of Brimonidine Tartrate

Used to treat open-angle glaucoma or ocular hypertension

What are the applications of Application

Brimonidine Tartrate is an α-2 receptor agonist

Properties of Brimonidine Tartrate

Melting point:	207-208°C (dec.)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO: 1 mg/ml; PBS (pH 7.2): 3 mg/ml
form	Solid
form	neat
color	White to off-white
CAS DataBase Reference	70359-46-5(CAS DataBase Reference)

Safety information for Brimonidine Tartrate

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.