Brimonidine Tartrate

Description

Brimonidine is an agonist of α₂-adrenergic receptors (α₂-ARs; K_is = 2.7, 52, and 44 nM for α_2A, α_2B, and α_2C-ARs, respectively, in CHO cells). It is selective for α₂-ARs over α₁-ARs (K_i = 1,800 nM in human brain). Brimonidine lowers intraocular pressure in DBA/2J mice, a model of glaucoma, to control levels when applied topically to the eye as a 0.1% solution. It also inhibits glutamate release, prevents upregulation of NMDA receptors containing NR1 and NR2A subunits, and protects rat retinal ganglion cells against glutamate excitotoxicity in a rat model of retinal ischemia when administered at a dose of 1 mg/kg per day. Formulations containing brimonidine have been used in the treatment of open-angle glaucoma and ocular hypertension.

Chemical properties

Off-White Crystalline Solid

The Uses of Brimonidine Tartrate

It is an a 2 receptor agonist. It is a drug used to treat glaucoma. It acts via decreasing aqueous humor synthesis

The Uses of Brimonidine Tartrate

It is an α2 receptor agonist. It is a drug used to treat glaucoma.

The Uses of Brimonidine Tartrate

Antitussive

The Uses of Brimonidine Tartrate

Used to treat open-angle glaucoma or ocular hypertension

What are the applications of Application

Brimonidine Tartrate is an α-2 receptor agonist