BREVETOXIN PBTX-3

Synonym(s):Brevetoxin PbTx-3, Ptychodiscus brevis - CAS 85079-48-7 - Calbiochem;Pumiliotoxin, Dihydrobrevetoxin B

CAS NO.：85079-48-7
Empirical Formula: C50H72O14
Molecular Weight: 897.1
MDL number: MFCD00214096
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-23 13:36:13

What is BREVETOXIN PBTX-3?

General Description

Lipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida. Voltage-dependent Na⁺ channel activator that causes contractile paralysis in animal models by binding to a unique site on these channels. The excitatory action of brevetoxins on nerve and muscle membranes is responsible for a wide spectrum of the toxic effects, including massive transmitter release from nerve endings, muscle fasciculations, and ventricular fibrillation. The toxin does not bind to either tetrodotoxin or aconitine/veratridine sites.

Biochem/physiol Actions

Primary TargetVoltage-dependent Na+ channel activator

Safety Profile

A poison by ingestion, intraperitoneal, and intravenous routes. When heated to decomposition it emits acrid smoke and irritating vapors.

Properties of BREVETOXIN PBTX-3

Density	1.190±0.06 g/cm3(Predicted)
storage temp.	-20C
solubility	DMSO: soluble,Ethanol: soluble,Methanol: soluble
pka	13.78±0.70(Predicted)
form	Solid
color	White to off-white

Safety information for BREVETOXIN PBTX-3

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Environment GHS09
GHS Hazard Statements	H300:Acute toxicity,oral H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P273:Avoid release to the environment. P391:Collect spillage. Hazardous to the aquatic environment P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P405:Store locked up.