1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate
- CAS NO.：203866-14-2
- Empirical Formula: C10H16FNO4
- Molecular Weight: 233.24
- MDL number: MFCD06796085
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-27 16:27:43
What is 1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate?
Chemical properties
White powder
The Uses of 1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate
N-Boc-trans-4-fluoro-L-proline is a useful synthetic intermediate. It is used to prepare potent 3- or 4-substituted-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors. It is also used to synthesize pyrrolotriazines derivatives as pan-Aurora kinase inhibitors and anti-tumor agents.
What are the applications of Application
N-Boc-trans-4-fluoro-L-proline is a useful boc protected chiral building block for chemical synthesis
Properties of 1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate
| Melting point: | 115-119°C |
| Boiling point: | 346.0±42.0 °C(Predicted) |
| Density | 1.24±0.1 g/cm3(Predicted) |
| refractive index | -69 ° (C=1, MeOH) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 3.53±0.40(Predicted) |
| color | White to Almost white |
| optical activity | [α]22/D -65.0±5°, c = 1 in chloroform |
| CAS DataBase Reference | 203866-14-2(CAS DataBase Reference) |
Safety information for 1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate
| InChIKey | YGWZXQOYEBWUTH-RQJHMYQMSA-N |
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