BOC-THIONOPHE-1-(6-NITRO)BENZOTRIAZOLIDE
- CAS NO.:184951-87-9
- Empirical Formula: C20H21N5O4S
- Molecular Weight: 427.48
- MDL number: MFCD01318725
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-27 16:27:43
What is BOC-THIONOPHE-1-(6-NITRO)BENZOTRIAZOLIDE?
The Uses of BOC-THIONOPHE-1-(6-NITRO)BENZOTRIAZOLIDE
BOC-THIONOPHE-1-(6-NITRO)BENZOTRIAZOLIDE can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthesis
To a solution of thioanilide 7 (2 mmol) dissolved
by gentle warming at 40 °C and then cooled to 0 °C in glacial
acetic acid (diluted with 5% water, 15 mL) was added NaNO2
(0.21 g, 3 mmol) in portions over 5 min with stirring. After 30
min, ice water (~100 mL) was added, and the precipitated
product was filtered and washed with water. The orange solid
was dried in vacuo at rt overnight and then at 50 °C for 4 h to
afford benzotriazoles 1-(N-BOC-L-thionophenylalaninyl)-6-nitrobenzotriazole (9b): yield 81%. as amorphous solids of
sufficient purity for use in the next step.
Properties of BOC-THIONOPHE-1-(6-NITRO)BENZOTRIAZOLIDE
Density | 1.36 |
storage temp. | -15°C |
pka | 10.06±0.46(Predicted) |
Safety information for BOC-THIONOPHE-1-(6-NITRO)BENZOTRIAZOLIDE
Computed Descriptors for BOC-THIONOPHE-1-(6-NITRO)BENZOTRIAZOLIDE
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