BMY 45778
Synonym(s):2-[3-[4-(4,5-diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid;BMY-045778;BMY45778
- CAS NO.:152575-66-1
- Empirical Formula: C26H18N2O5
- Molecular Weight: 438.43
- MDL number: MFCD00917043
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:03
What is BMY 45778?
The Uses of BMY 45778
BMY 45778 is an agonist for IP receptor to up-regulate the expression of C?/EBPβ and C?/EBPδ.
What are the applications of Application
BMY 45778 is a partial agonist at IP prostacyclin receptors
Definition
ChEBI: BMY 45778 is a bisoxazole. It has a role as a partial prostacyclin agonist.
Biological Activity
Non-prostanoid prostacyclin mimetic that acts as a partial agonist at IP 1 prostacyclin receptors. Potently inhibits platelet aggregation in vitro (IC 50 = 27-35 nM).
Biochem/physiol Actions
BMY 45778 is a non-prostanoid prostacyclin agonist.
References
[1]. seiler sm, brassard cl, federici me, et al. [3-[4-(4,5-diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid (bmy 45778) is a potent non-prostanoid prostacyclin partial agonist: effects on platelet aggregation, adenylyl cyclase, camp levels, protein kinase, and iloprost binding. prostaglandins, 1997, 53(1): 21-35.
[2]. wise h, qian ym, jones rl. a study of prostacyclin mimetics distinguishes neuronal from neutrophil ip receptors. eur j pharmacol, 1995, 278(3): 265-269.
Properties of BMY 45778
Boiling point: | 659.9±65.0 °C(Predicted) |
Density | 1.298±0.06 g/cm3(Predicted) |
storage temp. | room temp |
solubility | ≥67.6 mg/mL in DMSO |
pka | 3.10±0.10(Predicted) |
form | powder |
color | white to beige |
Safety information for BMY 45778
Computed Descriptors for BMY 45778
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