BMS-265246
- CAS NO.:582315-72-8
- Empirical Formula: C18H17F2N3O2
- Molecular Weight: 345.34
- MDL number: MFCD22420825
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:06
What is BMS-265246?
The Uses of BMS-265246
BMS-265246 is a potent and selective pyra-zolopyridine based inhibitor of cdk2/cyclinE, cdk1/cyclinB and cdk4/ cyclinD.
What are the applications of Application
BMS-265246 is a potent and selective Cdk1/Cdk2 inhibitor for Cdk1 and Cdk2, and Cdk4
Biological Activity
bms265246 is a potent and selective inhibitor for cdk1 and cdk2 (ic50= 6 nm and 9 nm)cyclin-dependent kinases (cdk) are a group of serine/threonine kinases. they are activated by coupling to cyclin and participate in the regulation of cell cycle.bms265246 inhibited the cdk4/cycd activity and prevented a2780 cytox (ic50 = 0.23 μm and 0.76 μm) [1]. in hct-116 cells, bms-265246 blocked the cell proliferation (ec50= 0.293 μm—0.492 μm). following the treatment of bms-265246, low dna intensity, large round nuclei and 4n dna content were observed in the dominant cell population –g2 arrested cells. [2]
storage
Store at -20°C
References
1. misra rn, xiao hy, rawlins db et al. 1h-pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-difluorophenacyl analogues. bioorgmed chem lett. 2003 jul 21;13(14):2405-8.2. sutherland jj, low j, blosser w et al. a robust high-content imaging approach for probing the mechanism of action and phenotypic outcomes of cell-cycle modulators. mol cancer ther. 2011 feb;10(2):242-54.
Properties of BMS-265246
Boiling point: | 552.9±50.0 °C(Predicted) |
Density | 1.304±0.06 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | insoluble in H2O; insoluble in EtOH; ≥17.25 mg/mL in DMSO |
form | solid |
pka | 8.50±0.40(Predicted) |
color | White to pink |
Safety information for BMS-265246
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for BMS-265246
New Products
Tubulysin I Tubulysin D Tubulysin M Tubulysin H Tubulysin E 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE 2,2-Difluoropropanol CYCLOBUTYLAMINE HYDROCHLORIDE Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 4-(Benzyloxy)-3-bromophenylacetic Acid 3-N-BOC-(S)-AMINO BUTYRONITRILE 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Imeglimin Hydrochloride IH Calcium Sodium Phosphosilicate IH Fuel shell Magnesium Trisilicate Latanoprostene Bunod Lubiprostone Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
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