Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listBLEOMYCIN A2

BLEOMYCIN A2

  • CAS NO.:11116-31-7
  • Empirical Formula: C55H84N17O21S3+
  • Molecular Weight: 1415.55
  • MDL number: MFCD00866496
  • EINECS: 2343565
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-04 17:34:31
BLEOMYCIN A2 Structural

What is BLEOMYCIN A2?

Description

The term “bleomycin” represents a group of glycopeptides used as cancer drugs and antibiotics. It was discovered in 1962 by microbiologist Hamao Umezawa at the Institute of Microbial Chemistry (Tokyo), who observed that culture filtrates of the bacterium Streptomyces verticillus had anticancer activity.
All bleomycins have the same general structure; they differ only by the functional group attached to the terminal amine. The most prominent member, bleomycin A2 (shown), contains a (dimethylsulfonio)propyl cation on the amine. It is marketed in the form of a sulfate salt that contains other bleomycins. The total synthesis of bleomycin A2 was reported in 1981 by Umezawa and colleagues at several Japanese research institutions. The commercial product, however, is obtained from S. verticillus.
Bleomycin sulfate is used primarily to treat Hodgkin and non-Hodgkin lymphoma; testicular and cervical cancers; squamous cell carcinomas; and cancer-related pleural effusion. It is administered via intravenous and intramuscular injection.
Biochemist JoAnne Stubbe at MIT (Cambridge, MA) was awarded the 2020 Priestley Medal for her work on enzyme mechanisms and for uncovering the details of the mechanism of action of bleomycin, which cleaves double-stranded DNA. Stephen J. Lippard, also at MIT, calls Stubbe “the top mechanistic biochemist of her generation”. The Priestley Medal for lifetime achievement in chemistry is the highest award given by ACS.

Definition

ChEBI: Bleomycin A2 is a bleomycin. It has a role as an antineoplastic agent and a metabolite.

Properties of BLEOMYCIN A2

Melting point: 200–204 oc (dec.)a
solubility  20 g/la
appearance white to yellowish powdera

Safety information for BLEOMYCIN A2

Computed Descriptors for BLEOMYCIN A2

Related products of tetrahydrofuran

You may like

  • 1-Methyl-6-oxo-1,6-dihydropyridazine-3-carbonitrile 98%
    1-Methyl-6-oxo-1,6-dihydropyridazine-3-carbonitrile 98%
    99903-60-3
    View Details
  • 88491-46-7 98%
    88491-46-7 98%
    88491-46-7
    View Details
  • 1823368-42-8 98%
    1823368-42-8 98%
    1823368-42-8
    View Details
  • 2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    1307449-08-6
    View Details
  • Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    25408-95-1
    View Details
  • 2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    1805639-70-6
    View Details
  • 1784294-80-9 98%
    1784294-80-9 98%
    1784294-80-9
    View Details
  • Lithium Clavulanate
    Lithium Clavulanate
    61177-44-4
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.