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HomeProduct name listBis(NHS)PEG5

Bis(NHS)PEG5

Synonym(s):Bis-N-succinimidyl-(pentaethylene glycol) ester;Bis-succinimide ester-activated PEG compound

Bis(NHS)PEG5 Structural

What is Bis(NHS)PEG5?

Description

Bis-PEG5-NHS ester is a PEG linker containing two NHS ester groups. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

The Uses of Bis(NHS)PEG5

Bis(NHS)PEG5 is used in targeting M2-like tumor-associated macrophages by using melittin-based pro-apoptotic peptide conjugates with anti-cancer drugs,

General Description

By contrast to typical PEG reagents that contain heterogeneous mixtures of different PEG chain lengths, this PEG reagent is a homogeneous compound of defined molecular weight and spacer arm length, providing greater precision in optimization and characterization of crosslinking applications. Homobifunctional crosslinkers containing N-hydroxysuccinimide (NHS) esters are often used for low-resolution 3-D studies of protein structure and protein interaction analysis.

Properties of Bis(NHS)PEG5

Boiling point: 632.5±65.0 °C(Predicted)
Density  1.37±0.1 g/cm3(Predicted)
storage temp.  -20°C
solubility  Soluble in DMSO, DCM, DMF
form  solid or viscous liquid
color  Colorless to Almost colorless
CAS DataBase Reference 756526-03-1

Safety information for Bis(NHS)PEG5

Computed Descriptors for Bis(NHS)PEG5

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