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HomeProduct name listBilobalide

Bilobalide

Synonym(s):Bilobalide

  • CAS NO.:33570-04-6
  • Empirical Formula: C15H18O8
  • Molecular Weight: 326.3
  • MDL number: MFCD00210481
  • EINECS: 608-892-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 19:05:58
Bilobalide Structural

What is Bilobalide?

Description

Bilobalide is a sesquiterpene lactone which is found in extracts of G. biloba. It has been shown to protect against cerebral edema, decrease cortical infarct volume, and reduce cerebral ischemic damage. Bilobalide, at 10 μM, reduces the release of glycine and glutamate from hippocampal slices under ischemic conditions. It also activates the rat constitutive androstane receptor at 100 μM and increases the levels and activities of several cytochrome P450 isoforms in rat liver microsomes.

The Uses of Bilobalide

Bilobalide provides protection against learning and memory impairment by reducing free radical injury and inhibiting neuronal apoptosis in the brain cortex and hippocampal CA1 region in induced vascular dementia rats.

The Uses of Bilobalide

Reference Standard in the analysis of herbal medicinal products

What are the applications of Application

Bilobalide is a compound with neuroprotective, antibacterial, and inhibitory effects

Definition

ChEBI: A terpenoid trilactone found in extracts of Ginkgo biloba.

General Description

Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

Enzyme inhibitor

This plant natural product (FW = 326.30 g/mol; CAS 33570-04-6) from the gingko tree (Ginkgo biloba) is a terpene trilactone that exhibits anticonvulsant properties. Bilobalide has multiple mechanisms of action (e.g., acting as a GABAA receptor antagonist (/1), preserving mitochondrial ATP synthesis, inhibiting staurosporine-induced apoptotic damage, suppressing hypoxia-induced membrane deterioration in the brain, and increasing the expression the mitochondrial DNA-encoded COX III subunit of cytochrome c oxidase and the ND1 subunit of NADH dehydrogenase). Bilobalide was later synthesized in E. J. Corey’s laboratory in the late 1980s.

Properties of Bilobalide

Melting point: >300°
alpha  57820 -64.3° (c = 2 in acetone)
Boiling point: 651.7±55.0 °C(Predicted)
Density  1.56±0.1 g/cm3(Predicted)
storage temp.  −20°C
solubility  Acetone (Slightly), Methanol (Slightly)
form  neat
form  Solid
pka 11.74±0.40(Predicted)
color  White to Off-White
Merck  14,1220
Stability: Hygroscopic
CAS DataBase Reference 33570-04-6(CAS DataBase Reference)

Safety information for Bilobalide

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Exclamation Mark
Irritant
GHS07
ghs
Environment
GHS09
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H317:Sensitisation, Skin
H318:Serious eye damage/eye irritation
H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P272:Contaminated work clothing should not be allowed out of the workplace.
P273:Avoid release to the environment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P391:Collect spillage. Hazardous to the aquatic environment
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.
P501:Dispose of contents/container to..…

Computed Descriptors for Bilobalide

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