BIIE 0246
- CAS NO.:246146-55-4
- Empirical Formula: C49H57N11O6
- Molecular Weight: 896.05
- MDL number: MFCD09878236
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:03
What is BIIE 0246?
The Uses of BIIE 0246
BIIE 0246, is a selective non-peptide antagonist which binds to the neuropeptide NPY2-R in a competitive manner. Studies have also shown that BIIE 0246 is highly lipophilic and as a result BIIE 0246 builds up at membranes near the receptors.
What are the applications of Application
BIIE 0246 is a selective and competitive NPY2-R antagonist
Biological Activity
Potent, selective and competitive non-peptide antagonist for the neuropeptide Y Y 2 receptor (IC 50 = 15 nM). Displays > 650-fold selectivity over Y 1 , Y 4 and Y 5 receptors. Active in vivo .
References
[1]. doods h, gaida w, wieland ha, et al. biie0246: a selective and high affinity neuropeptide y y(2) receptor antagonist. eur j pharmacol, 1999, 384(2-3): r3-5.
[2]. el bahh b, cao jq, beck-sickinger ag, et al. blockade of neuropeptide y(2) receptors and suppression of npy's anti-epileptic actions in the rat hippocampal slice by biie0246. br j pharmacol, 2002, 136(4): 502-509.
[3]. dumont y, cadieux a, doods h, et al. biie0246, a potent and highly selective non-peptide neuropeptide y y(2) receptor antagonist. br j pharmacol, 2000, 129(6): 1075-1088.
[4]. abbott cr, small cj, kennedy ar, et al. blockade of the neuropeptide y y2 receptor with the specific antagonist biie0246 attenuates the effect of endogenous and exogenous peptide yy(3-36) on food intake. brain res, 2005, 1043(1-2): 139-144.
[5]. bacchi f, mathé aa, jiménez p, et al. anxiolytic-like effect of the selective neuropeptide y y2 receptor antagonist biie0246 in the elevated plus-maze. peptides, 2006, 27(12): 3202-3207.
Properties of BIIE 0246
Density | 1.38±0.1 g/cm3(Predicted) |
storage temp. | Store at +4°C |
solubility | <67.2mg/ml in DMSO; <23.55mg/ml in ethanol |
form | solid |
pka | 13.28±0.40(Predicted) |
color | White |
Safety information for BIIE 0246
Computed Descriptors for BIIE 0246
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Rimegepant Impurity 3 Ivermectin EP Impurity B Tubulysin F Tubulysin B Tubulysin E Tubulysin H Tubulysin M (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Calcium Sodium Phosphosilicate IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Fuel shell Imeglimin Hydrochloride IH Benzene butanoic acid, 2-hydroxy-3-iodo-, methyl ester (S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopyrrolidin-3-yl)propanoate 4-Bromo-N,N-bis(4-iodophenyl)aniline 5-Aminophthalazine Methyl 4-amino-3-(dihexylamino)benzoate 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione 2-chloro-N-(biphenyl-2-yl) nicotinamide 4-bromo-2,5-difluoro benzoic acidRelated products of tetrahydrofuran
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