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HomeProduct name listBifluranol

Bifluranol

Bifluranol Structural

What is Bifluranol?

Definition

ChEBI: (2S,3R)-bifluranol is a 4,4'-pentane-2,3-diylbis(2-fluorophenol) that has (2S,3R)-stereoconfiguration. It is an enantiomer of a (2R,3S)-bifluranol.

Biological Activity

Bifluranol (BX341) has anti-androgenic activity.

in vivo

The absorption, distribution and excretion of Bifluranol have been studied in mouse, rat, ferret and dog. It is readily absorbed following oral administration, but blood concentrations of Bifluranol are low due to hepatic uptake and biliary excretion. After intravenous administration of [ 3 H]it to rats (200 μg/kg) and ferrets (60 μg/kg) the blood concentrations of 3 H decreases rapidly for the first 2 to 3 h, with the decrease being more rapid in females ( 18 min for rat, 30 min for ferret) than males (1.0 h for rat, 1.4 h for ferret). This is followed by a much slower decline (40 h for rat). , 20 h for ferret) to concentrations at 96 h of less than 15 ng Bifluranol equivalents mL -1 (rat) or 1 ng Bifluranol equivalents mL -1 (ferret).

Properties of Bifluranol

Melting point: 158-159°
Boiling point: 361.6±37.0 °C(Predicted)
Density  1?+-.0.06 g/cm3(Predicted)
storage temp.  Store at -20°C
solubility  Soluble in DMSO
form  Solid
pka 8.85±0.31(Predicted)
color  White to off-white

Safety information for Bifluranol

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Bifluranol

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