BIBX 1382 DIHYDROCHLORIDE

Synonym(s):EGFR Inhibitor II, BIBX1382 - CAS 196612-93-8 - Calbiochem;N⁸-(3-Chloro-4-fluorophenyl)-N²-(1-methylpiperidin-4-yl)-pyrimido[5,4-d]pyrimidine-2,8-diamine, 2HCl, BIBX1382BS

CAS NO.：196612-93-8
Empirical Formula: C18H19ClFN7
Molecular Weight: 387.84
MDL number: MFCD09838900
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 15:53:33

What is BIBX 1382 DIHYDROCHLORIDE?

The Uses of BIBX 1382 DIHYDROCHLORIDE

BIBX 1382 Dihydrochloride, is a potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM).

The Uses of BIBX 1382 DIHYDROCHLORIDE

Falnidamol is a novel ErbB receptor kinase inhibitor that is more potent at inhibiting signaling induced by TGF-α than that induced by neuregulin1-β1 or anti-ErbB2 agonist antibodies.

What are the applications of Application

BIBX 1382 is a potent, reversible, selective inhibitor of EGFR

Definition

ChEBI: N4-(3-chloro-4-fluorophenyl)-N6-(1-methyl-4-piperidinyl)pyrimido[5,4-d]pyrimidine-4,6-diamine is a substituted aniline.

Biological Activity

Potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC 50 = 3 nM). Displays > 1000-fold lower potency against ErbB2 (IC 50 = 3.4 μ M) and a range of other related tyrosine kinases (IC 50 > 10 μ M). Oral administration inhibits growth of established human xenografts in athymic mice.

References

1. f. f. solca, a. baum, e. langkopf, g. dahmann, k. h. heider, f. himmelsbach and j. c. van meel, j pharmacol exp ther 2004, 311, 502-509.

Properties of BIBX 1382 DIHYDROCHLORIDE

Melting point:	>217°C (dec.)
Boiling point:	552.0±60.0 °C(Predicted)
Density	1.427
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	8?+-.0.10(Predicted)
color	Pale Yellow to Yellow

Safety information for BIBX 1382 DIHYDROCHLORIDE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.