BENZYL AZIDE
Synonym(s):α-Azidotoluene solution;(Azidomethyl)benzene solution
- CAS NO.:622-79-7
- Empirical Formula: C7H7N3
- Molecular Weight: 133.15
- MDL number: MFCD00013836
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is BENZYL AZIDE?
The Uses of BENZYL AZIDE
BENZYL AZIDE was used in the synthesis of stable 1,2,3-triazole derivatives.
The Uses of BENZYL AZIDE
Benzyl azide is used in the synthesis of 1,2,3-triazole derivatives. It serves as a reagent used to introduce a PhCH2N group into a molecule.
What are the applications of Application
(Azidomethyl)benzene is a useful azide for proteomics research
Synthesis Reference(s)
Tetrahedron Letters, 16, p. 471, 1975 DOI: 10.1016/S0040-4039(00)71896-X
Journal of the American Chemical Society, 91, p. 4323, 1969 DOI: 10.1021/ja01043a071
General Description
Benzyl azide is an aromatic azide generally used in copper(I)-catalyzed azide-alkyne cycloaddition reactions.
Safety Profile
A heat-sensitive explosive.Explosive reaction with bis(trifluoromethyl)nitroxide.Upon decomposition it emits toxic fumes of NOx. Seealso AZIDES.
Synthesis
Sodium azide (3.58 g, 55.0 mmol) was added to DMSO (120 mL) and stirred
vigorously until fully dissolved. Benzyl bromide 168 (6.54 mL, 55 mmol)
was added. The reaction mixture was stirred at RT overnight. The
colourless liquid was worked up with water (100 mL), and extracted with
diethyl ether (3 x 100 mL). The extractions were washed with water (2 x
80 mL) and brine (80 mL). The ether layer was dried over MgSO4 and after
filtration, it was evaporated to dryness, giving benzyl azide 73 as a
colourless oil (6.9 g, 51.8 mmol, 94%): IR (neat) νm a x / cm– 1 3455, 3028,
2970, 2946, 2093, 1605, 1586, 1496, 1454, 1349, 1252; 1H NMR (400 MHz,
CDCl 3 ) δ 7.44 – 7.28 (m, 5H), 4.33 (s, 2H); 1 3C NMR (100 MHz, CDCl 3 ) δ
135.55, 129.05, 128.52, 128.44, 55.00.
Properties of BENZYL AZIDE
Melting point: | 157℃ |
Boiling point: | 81-83°C 16mm |
Density | 1.0655 |
refractive index | 1.5341 |
RTECS | XS6650000 |
Flash point: | 82-85°C/16mm |
storage temp. | 2-8°C |
form | Liquid |
Specific Gravity | 1.0655 |
Water Solubility | Insoluble in waterMiscible with ethanol and diethyl ether. Immiscible with water. |
BRN | 636825 |
CAS DataBase Reference | 622-79-7(CAS DataBase Reference) |
Safety information for BENZYL AZIDE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 Health Hazard GHS08 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H336:Specific target organ toxicity,single exposure; Narcotic effects H351:Carcinogenicity H373:Specific target organ toxicity, repeated exposure |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for BENZYL AZIDE
Abamectin manufacturer
REDDY N REDDY PHARMACEUTICALS
ALS INDIA LIFE SCIENCES
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