Benzyl 2-chloroacetate
- CAS NO.:140-18-1
- Empirical Formula: C9H9ClO2
- Molecular Weight: 184.62
- MDL number: MFCD00157062
- EINECS: 205-400-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-18 18:48:51
What is Benzyl 2-chloroacetate?
Chemical properties
Benzyl 2-chloroacetate is a colorless, slightly viscous liquid. Insoluble in water, soluble in alcohol and oils. Sp.Gr = 1.22. Mild, Jasmin-type odor, floral-fruity, of considerable tenacity.
The Uses of Benzyl 2-chloroacetate
Benzyl chloroacetate may be used:
- in the synthesis of monoesters of phosphonoacetic acid
- in the synthesis of N-benzoyl-glycyl- hydroxyl acetic acid, ester substrate for carboxypeptidase Y catalyzed peptide synthesis
- as reagent in the total syntheses of the (±)-di-O-methyl ethers of the norlignans sequirin-A, agatharesinol, and hinokiresinol, and of (±)-tri-O-methyl sequirin-E
Preparation
From Benzyl alcohol and Monochloroacetic acid by direct esterification under azeotropic conditions.
General Description
Benzyl chloroacetate is an ester. Could find usc in Jasmin, Lilac. Appleblossom fragrances, particularly for soap, where this ester has greater fixative effect than the Benzyl acetate. However, this ester must be absolutely acid-free to be permitted or recommended for use in any cosmetic product. The acid is highly corrosive. Older odor-descriptions of this ester seem to indicate that the product has not always been very pure.
Safety Profile
Moderately toxic byintraperitoneal route. When heated todecomposition it emits toxic fumes of Cl- .
Properties of Benzyl 2-chloroacetate
Boiling point: | 90 °C/1 mmHg (lit.) |
Density | 1.215 g/mL at 25 °C (lit.) |
refractive index | n |
Flash point: | >230 °F |
storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
form | clear liquid |
color | Oil |
Specific Gravity | 1.215 |
Water Solubility | insoluble |
CAS DataBase Reference | 140-18-1(CAS DataBase Reference) |
EPA Substance Registry System | Acetic acid, chloro-, phenylmethyl ester (140-18-1) |
Safety information for Benzyl 2-chloroacetate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Benzyl 2-chloroacetate
Abamectin manufacturer
Ralington Pharma
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