Benzyl 2-chloroacetate

CAS NO.：140-18-1
Empirical Formula: C9H9ClO2
Molecular Weight: 184.62
MDL number: MFCD00157062
EINECS: 205-400-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-18 18:48:51

What is Benzyl 2-chloroacetate?

Chemical properties

Benzyl 2-chloroacetate is a colorless, slightly viscous liquid. Insoluble in water, soluble in alcohol and oils. Sp.Gr = 1.22. Mild, Jasmin-type odor, floral-fruity, of considerable tenacity.

The Uses of Benzyl 2-chloroacetate

Benzyl chloroacetate may be used:

in the synthesis of monoesters of phosphonoacetic acid
in the synthesis of N-benzoyl-glycyl- hydroxyl acetic acid, ester substrate for carboxypeptidase Y catalyzed peptide synthesis
as reagent in the total syntheses of the (±)-di-O-methyl ethers of the norlignans sequirin-A, agatharesinol, and hinokiresinol, and of (±)-tri-O-methyl sequirin-E

Preparation

From Benzyl alcohol and Monochloroacetic acid by direct esterification under azeotropic conditions.

General Description

Benzyl chloroacetate is an ester. Could find usc in Jasmin, Lilac. Appleblossom fragrances, particularly for soap, where this ester has greater fixative effect than the Benzyl acetate. However, this ester must be absolutely acid-free to be permitted or recommended for use in any cosmetic product. The acid is highly corrosive. Older odor-descriptions of this ester seem to indicate that the product has not always been very pure.

Safety Profile

Moderately toxic byintraperitoneal route. When heated todecomposition it emits toxic fumes of Cl^- .

Properties of Benzyl 2-chloroacetate

Boiling point:	90 °C/1 mmHg (lit.)
Density	1.215 g/mL at 25 °C (lit.)
refractive index	n20/D 1.525(lit.)
Flash point:	>230 °F
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	clear liquid
color	Oil
Specific Gravity	1.215
Water Solubility	insoluble
CAS DataBase Reference	140-18-1(CAS DataBase Reference)
EPA Substance Registry System	Acetic acid, chloro-, phenylmethyl ester (140-18-1)

Safety information for Benzyl 2-chloroacetate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.