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HomeProduct name listBENZPHETAMINE HYDROCHLORIDE--DEA

BENZPHETAMINE HYDROCHLORIDE--DEA

  • CAS NO.:5411-22-3
  • Empirical Formula: C17H21N.ClH
  • Molecular Weight: 275.821
  • MDL number: MFCD00058090
  • EINECS: 226-489-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-18 14:08:52
BENZPHETAMINE HYDROCHLORIDE--DEA Structural

What is BENZPHETAMINE HYDROCHLORIDE--DEA?

Originator

Didrex,Upjohn,US,1960

The Uses of BENZPHETAMINE HYDROCHLORIDE--DEA

The S-enantiomer of Benzphetamine (B209880). Controlled substance (stimulant). Anorexic.

Definition

ChEBI: The hydrochloride salt of benzphetamine. A sympathomimetic agent with properties similar to dextroamphetamine, it is used in the treatment of obesity.

Manufacturing Process

Fifty grams of d-desoxyephedrine hydrochloride was dissolved in a small amount of water and a molar excess of sodium hydroxide was .added thereto. The resulting forty grams of precipitated oily d-desoxyephedrine was collected in ether and the whole was thereafter dried with anhydrous potassium carbonate. The ether was then removed, the resulting oily residue having an nD22 of 1.5045 was stirred in a flask with 40 grams of anhydrous sodium carbonate at 120°C, and 34.6 grams of benzyl chloride was added dropwise thereto over a period of thirty minutes. Stirring was continued for 2 hours, whereafter the reaction mixture was extracted with benzene.
The benzene was distilled from the extract and the residue of d-N-methyl-Nbenzyl-β-phenylisopropylamine was distilled at reduced pressure. The thus obtained free base, distilling at 127°C at a pressure of 0.2 mm of mercury and having an nD19 of 1.5515, was dissolved in ethyl acetate and a molar equivalent of ethanolic hydrogen chloride was added thereto. Anhydrous ether was added to the mixture and d-N-methyl-N-benzyl-β-phenylisopropylamine hydrochloride precipitated from the reaction mixture as an oil which was crystallized from ethyl acetate to give crystals melting at 129° to 130°C.

brand name

Didrex (Pharmacia & Upjohn).

Therapeutic Function

Antiobesity

Properties of BENZPHETAMINE HYDROCHLORIDE--DEA

Melting point: 129-130°
Flash point: 11 °C
storage temp.  2-8°C
solubility  DMF: 3 mg/ml; DMSO: 5 mg/ml; Ethanol: 20 mg/ml; Methanol: 1 mg/ml; PBS (pH 7.2): 5 mg/ml
form  A crystalline solid
EPA Substance Registry System Benzphetamine hydrochloride (5411-22-3)

Safety information for BENZPHETAMINE HYDROCHLORIDE--DEA

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Health Hazard
GHS08
GHS Hazard Statements H361:Reproductive toxicity
Precautionary Statement Codes P201:Obtain special instructions before use.
P202:Do not handle until all safety precautions have been read and understood.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Computed Descriptors for BENZPHETAMINE HYDROCHLORIDE--DEA

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