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HomeProduct name listBEAUVERICIN

BEAUVERICIN

Synonym(s):cyclo(D-α-Hydroxyisovaleryl-L-N-methyl-Phe)3

  • CAS NO.:26048-05-5
  • Empirical Formula: C45H57N3O9
  • Molecular Weight: 783.95
  • MDL number: MFCD30541349
  • EINECS: 618-347-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-31 18:15:48
BEAUVERICIN Structural

What is BEAUVERICIN?

Description

Beauvericin (CAS 26048-05-5) induces apoptosis in A549 cancer cells.1 Disrupts mitochondrial volume regulation.2 Antifungal activity acting via inhibition of both multidrug efflux and TORC1 kinase.3 Crosses the blood-brain barrier in mice.4 Inhibits HIV-1 integrase.5

Chemical properties

White powder

The Uses of BEAUVERICIN

Toxic depsipeptide with antibiotic and insecticidal effects.Beauvericin is a toxic depsipeptide with antibiotic and insecticidal effects.

The Uses of BEAUVERICIN

Beauvericin is a cyclic depsipeptide isolated from several fungal genera, notably Beauveria and Fusarium, first reported in 1969. Beauvericin exhibits broad antifungal, antibacterial, antiprotozoan and insecticidal activities. At the molecular level, beauvericin exhibits ionophoric properties, and inhibits acyl-CoA:cholesterol acyltransferase activity. Beauvericin induces apoptosis by elevating intracellular calcium levels.

What are the applications of Application

Beauvericin is an enniatin family mycotoxin

Definition

ChEBI: A trimeric cyclodepsipeptide composed from alternating methylphenylalanyl and hydroxyvaleryl residues.

References

1) Lu et al. (2016), Beauvericin-induced cell apoptosis through the mitogen-activated protein kinase pathway in human nonsmall cell lung cancer A549 cells.; J. Toxicol. Sci., 41 429 2) Tonshin et al. (2010), The Fusarium mycotoxins enniatins and beauvericin cause mitochondrial dysfunction by affecting the mitochondrial volume regulation, oxidative phosphorylation and ion homeostasis.; Toxicology, 276 49 3) Shekhar-Guturja et al. (2016), Dual action antifungal small molecule modulates multidrug efflux and TOR signaling; Nat. Chem. Biol., 12 867 4) Taevernier et al. (2016), Blood-brain barrier transport kinetics of the cyclic depsipeptide mycotoxins beauvericin and enniatins; Toxicol. Lett., 258 175 5) Shin et al. (2009), Beauvericin and enniatins H,I and MK1688 are new potent inhibitors of human immunodeficiency virus type-1 integrase; J. Antibiot. (Tokyo), 62 687

Properties of BEAUVERICIN

Melting point: 93-94℃
Boiling point: 975.6±65.0 °C(Predicted)
Density  1.126±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  Soluble in DMSO (30 mg/ml)
form  neat
pka -1.02±0.70(Predicted)
form  Solid
color  White
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety information for BEAUVERICIN

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for BEAUVERICIN

InChIKey GYSCAQFHASJXRS-ABKJGVMTSA-N

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