Azatepa
- CAS NO.：125-45-1
- Empirical Formula: C8H14N5OPS
- Molecular Weight: 259.273
- MDL number: MFCD00866515
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:32
What is Azatepa?
Originator
Azatepa,ZYF Pharm Chemical
The Uses of Azatepa
Antineoplastic.
Definition
ChEBI: Azatepa is a phosphoramide.
Manufacturing Process
N-Ethyl-N-(1,3,4-thiadiazol-2-yl)amidophosphoryl chloride is prepared by
refluxing 16.4 parts of 2-ethylamino-1,3,4-thiadiazole hydrochloride with 84
parts of phosphorus oxychloride for 6 h and then removing the excess
phosphorus oxychloride by distillation under reduced pressure. The residual oil
is washed with cold petroleum ether, dried and dissolved in 310 parts of dry
benzene.
The solution of N-ethyl-N-(1,3,4-thiadiazol-2-yl)amidophosphoryl chloride is
added slowly at 10°C to a mixture of 9.5 parts of ethylenimine, 30.3 parts of
triethylamine, and 44 parts of warm dry benzene. Agitation is continued for 2
h without cooling after which the triethylamine hydrochloride is filtered off.
The benzene is distilled from the filtrate under reduced pressure, and the
N,N'-diethylene-N''-ethyl-(N'-(1,3,4-thiadiazo-2-yl)phosphoramide is
recrystallized from hexane, melting point 95°-96°C.
Therapeutic Function
Antineoplastic
Safety information for Azatepa
New Products
4-Fluorophenylacetic acid 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate (6-METHYL-[1,3]DITHIOLO[4,5-b]QUINOXALIN-2-ONE INDAZOLE-3-CARBOXYLIC ACID 4-IODO BENZOIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5,6-Dimethoxyindanone 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 2-aminopropyl benzoate hydrochloride 1-(4-(aminomethyl)benzyl)urea hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
You may like
-
2033-24-1 98%View Details
2033-24-1 -
42831-50-5 5-METHYLISOXAZOLE-4-CARBOXYLIC ACID 98%View Details
42831-50-5 -
1975-50-4 98%View Details
1975-50-4 -
2-HYDROXY BENZYL ALCOHOL 98%View Details
90-01-7 -
2-Chloro-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate 221615-75-4 98%View Details
221615-75-4 -
61397-56-6 CIS BROMO BENZOATE 98%View Details
61397-56-6 -
14714-50-2 (2-Hydroxyphenyl)acetonitrile 98+View Details
14714-50-2 -
118753-70-1 98+View Details
118753-70-1