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HomeProduct name listATROPINE METHYL NITRATE

ATROPINE METHYL NITRATE

Synonym(s):AMN;Methylatropine nitrate

  • CAS NO.:52-88-0
  • Empirical Formula: C18H26N2O6
  • Molecular Weight: 366.41
  • MDL number: MFCD00050294
  • EINECS: 200-156-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-28 23:16:16
ATROPINE METHYL NITRATE Structural

What is ATROPINE METHYL NITRATE?

Chemical properties

mp 162-164 C

Originator

Methylatropine,Paganfarma

The Uses of ATROPINE METHYL NITRATE

Atropine methyl nitrate has been used to suppress mucus production and respiratory secretions in rats. It has also been used to study its effects on xanomeline-induced suppression of serum tumor necrosis factor.

The Uses of ATROPINE METHYL NITRATE

antibacterial

The Uses of ATROPINE METHYL NITRATE

cephalosporin antimicrobial

Manufacturing Process

There are 2 methods of synthesis of methyl atropine nitrate:
1) To a solution of 28.9 g atropine of in 100 g of methanol was added at 110°C for 2 hours 7.7 g methyl nitrate. Methanol was evaporated and methyl atropine nitrate was crystallysed, M.P. 163°C.
2) To a solution of 70.4 g methyl atropine sulfate (prepared from methyl atropine chloride and silver nitrate) in water was added aqueous solution of 26.1 g barium nitrate. Barium sulfate was deleted by filtration. Filtrate was concentrated and the methyl atropine nitrate was obtained.

brand name

Ekomine (Hoechst-Roussel); Eumydrin (Sterling Winthrop).

Therapeutic Function

Anticholinergic, Mydriatic, Spasmolytic

Biochem/physiol Actions

Atropine methyl nitrate is a muscarinic acetylcholine receptor antagonist that does not cross the blood brain barrier. Atropine methyl nitrate has been used for its peripheral muscarinic effects (bladder, respiratory, to block parasympathetic signaling to the heart, etc.) and to separate central from peripheral effects or protect against peripheral side effects when using muscarinics that do cross the blood brain barrier.

Safety Profile

Poison by intraperitoneal, intravenous, and subcutaneous routes. Moderately toxic by ingestion. Human systemic effects: mydriasis. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also ATROPINE and NITRATES.

Properties of ATROPINE METHYL NITRATE

Melting point: 163°C
storage temp.  -20°C
solubility  H2O: 50 mg/mL
form  powder
color  white
Merck  875
CAS DataBase Reference 52-88-0(CAS DataBase Reference)
EPA Substance Registry System Methylatropine nitrate (52-88-0)

Safety information for ATROPINE METHYL NITRATE

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
Precautionary Statement Codes P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P284:Wear respiratory protection.
P310:Immediately call a POISON CENTER or doctor/physician.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Computed Descriptors for ATROPINE METHYL NITRATE

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