ATROPINE METHYL NITRATE
Synonym(s):AMN;Methylatropine nitrate
- CAS NO.:52-88-0
- Empirical Formula: C18H26N2O6
- Molecular Weight: 366.41
- MDL number: MFCD00050294
- EINECS: 200-156-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is ATROPINE METHYL NITRATE?
Chemical properties
mp 162-164 C
Originator
Methylatropine,Paganfarma
The Uses of ATROPINE METHYL NITRATE
Atropine methyl nitrate has been used to suppress mucus production and respiratory secretions in rats. It has also been used to study its effects on xanomeline-induced suppression of serum tumor necrosis factor.
The Uses of ATROPINE METHYL NITRATE
antibacterial
The Uses of ATROPINE METHYL NITRATE
cephalosporin antimicrobial
Manufacturing Process
There are 2 methods of synthesis of methyl atropine nitrate:
1) To a solution of 28.9 g atropine of in 100 g of methanol was added at
110°C for 2 hours 7.7 g methyl nitrate. Methanol was evaporated and methyl
atropine nitrate was crystallysed, M.P. 163°C.
2) To a solution of 70.4 g methyl atropine sulfate (prepared from methyl
atropine chloride and silver nitrate) in water was added aqueous solution of
26.1 g barium nitrate. Barium sulfate was deleted by filtration. Filtrate was
concentrated and the methyl atropine nitrate was obtained.
brand name
Ekomine (Hoechst-Roussel); Eumydrin (Sterling Winthrop).
Therapeutic Function
Anticholinergic, Mydriatic, Spasmolytic
Biochem/physiol Actions
Atropine methyl nitrate is a muscarinic acetylcholine receptor antagonist that does not cross the blood brain barrier. Atropine methyl nitrate has been used for its peripheral muscarinic effects (bladder, respiratory, to block parasympathetic signaling to the heart, etc.) and to separate central from peripheral effects or protect against peripheral side effects when using muscarinics that do cross the blood brain barrier.
Safety Profile
Poison by intraperitoneal, intravenous, and subcutaneous routes. Moderately toxic by ingestion. Human systemic effects: mydriasis. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also ATROPINE and NITRATES.
Properties of ATROPINE METHYL NITRATE
Melting point: | 163°C |
storage temp. | -20°C |
solubility | H2O: 50 mg/mL |
form | powder |
color | white |
Merck | 875 |
CAS DataBase Reference | 52-88-0(CAS DataBase Reference) |
EPA Substance Registry System | Methylatropine nitrate (52-88-0) |
Safety information for ATROPINE METHYL NITRATE
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P284:Wear respiratory protection. P310:Immediately call a POISON CENTER or doctor/physician. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for ATROPINE METHYL NITRATE
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