ATPA
Synonym(s):(RS)-2-Amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoic acid
- CAS NO.：140158-50-5
- Empirical Formula: C10H16N2O4
- Molecular Weight: 228.25
- MDL number: MFCD01860864
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is ATPA?
The Uses of ATPA
(R,S)-ATPA is a selective and potent GluR5 kainate receptor agonist (1,2). It inhibits GluK2 kainate receptor-JNK3 protein pathway by activating GABA type A receptor in rat after cerebral ischemia-reperfusion injury (3). (R,S)-ATPA is a neuroprotective agent.
What are the applications of Application
(R,S)-ATPA is a potent and selective agonist of the GluR5 subtype of the kainate receptor
Definition
ChEBI: 2-amino-3-(5-tert-butyl-3-oxo-4-isoxazolyl)propanoic acid is an alpha-amino acid.
Biological Activity
A selective and potent GluR5 kainate receptor agonist (K i = 4.3 nM), inactive at GluR6 (K i > 1 mM) and only weakly active at AMPA receptors (GluR1-4) and the kainate receptors KA-2 and GluR7 (K i values of 6 - 14 μ M). Also available as part of the Kainate Receptor Tocriset™ .
storage
Desiccate at +4°C
Properties of ATPA
| Density | 1.263±0.06 g/cm3(Predicted) |
| storage temp. | Desiccate at +4°C |
| solubility | DMSO: 10 mg/mL |
| form | solid |
| pka | 2.15±0.10(Predicted) |
| color | white |
Safety information for ATPA
Computed Descriptors for ATPA
New Products
Tert-butyl bis(2-chloroethyl)carbamate 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL N-octanoyl benzotriazole 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid DIETHYL AMINOMALONATE HYDROCHLORIDE 1,1’-CARBONYLDIIMIDAZOLE R-2-BENZYLOXY PROPIONIC ACID 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) N-METHYL INDAZOLE-3-CARBOXYLIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
![(R,S)-2-AMINO-3-[5-TERT-BUTYL-3-(PHOSPHONOMETHOXY)-4-ISOXAZOLYL]PROPIONIC ACID](https://img.chemicalbook.in/StructureFile/ChemBookStructure6/GIF/CB5396117.gif)
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