asterric acid
- CAS NO.:577-64-0
- Empirical Formula: C17H16O8
- Molecular Weight: 348.3
- MDL number: MFCD00216131
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 16:48:35
What is asterric acid?
The Uses of asterric acid
Asterric acid is a fungal metabolite with anti-angiogenic properties, isolated from a number of Aspergillus and Penicillium species. It is an inhibitor of vascular endothelial growth factor (VEGF), inhibiting VEGF-induced tube formation of human umbilical vein endothelial cells.
What are the applications of Application
Asterric acid is an antibiotic, fungal metabolite
Biological Activity
asterric acid is an eta receptor inhibitor.endothelin (et), a potent vasoconstrictor/pressor peptide consisting of 21 amino acid residues, was first isolated from the cultures of porcine aortic endothelial cells. analyses of a human genomic library reveals three forms of et (et-1, et-2 and et-3) with more than 70% homology with one another. in various organs, high affinity and specific receptors for et have been found, which have been classfied as receptors eta and etb. et-1 has potent and long-lasting vasoconstrictive activity, as a result of binding to the eta receptor.
in vitro
previous study asterric acid isolated as an active substance from the culture filtrate of a fungus, aspergillus sp. asterric acid had also been reported as a metabolite of a fungus. it was found that asterric acid had the property of inhibiting et-1 binding to the eta receptor of a10 cells, but it showed no inhibitory activity against anp and a ii binding at 10 mm, which indicated that asterric acid displayed as a specific inhibitor of et-1 binding [1].
References
[1] ohashi, h. ,akiyama, h.,nishikori, k., et al. asterric acid, a new endothelin binding inhibitor. journal of antibiotics 45, 1684-1685 (1992).
Properties of asterric acid
Melting point: | 208-214 °C |
Boiling point: | 557.6±50.0 °C(Predicted) |
Density | 1.406±0.06 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | Soluble in ethanol;Soluble in DMSO;Soluble in dimethyl formamide |
form | solid |
pka | 2.97±0.34(Predicted) |
color | white |
Safety information for asterric acid
Signal word | Warning |
Pictogram(s) |
Environment GHS09 |
GHS Hazard Statements |
H410:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P273:Avoid release to the environment. P501:Dispose of contents/container to..… |
Computed Descriptors for asterric acid
New Products
ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound ARelated products of tetrahydrofuran
You may like
-
Asterric acid CAS 577-64-0View Details
577-64-0 -
Dechloro DesloratadineView Details
-
Dehydro DesloratadineView Details
-
Edoxaban Impurity 57View Details
2089454-69-1 -
Eltrombopag N-Oxide ImpurityView Details
2734533-17-4 -
Empagliflozin Bromo ImpurityView Details
-
Glycopyrronium Bromide EP Impurity IView Details
1404617-94-2 -
Ipratropium EP Impurity BView Details
58073-59-9