Aspartate aminotransferase
Synonym(s):L -Aspartate:2-oxoglutarate aminotransferase;Aspartate Aminotransferase;GOT
- CAS NO.:9000-97-9
- Empirical Formula: C13H17NO2
- Molecular Weight: 219.27958
- MDL number: MFCD00131191
- EINECS: 232-571-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:16
What is Aspartate aminotransferase?
The Uses of Aspartate aminotransferase
Converts L-aspartate and alpha-ketoglutarate to oxaloacetate and L-glutamate
Definition
An enzyme that catalyzes reversibly the transfer of an amino group from glutamic acid to oxaloacetic acid, yielding α-ketoglutaric acid and aspartic acid. The codons for aspartate are GAC and GAU.
General Description
Glutamic-Oxalacetic Transaminase is found in all tissues and is predominant in the liver and skeletal muscle. It is a prototype of fold-type I pyridoxal 5′-phosphate (PLP)-enzymes. Glutamic-oxalacetic transaminase is a homodimer containing large and small domains in each subunit.
Biochem/physiol Actions
Glutamic-oxalacetic transaminase or aspartate aminotransferase (AAT) catalyzes the interconversion of L-aspartate and α-ketoglutarate with oxalacetate and L-glutamate. This reversible transaminase reaction is dependent on pyridoxal 5′-phosphate (PLP). Glutamic-oxalacetic transaminase maintains the nitrogen currency for metabolism by generating L-glutamate. Elevated serum levels of glutamic-oxalacetic transaminase are indicated in myocardial infarction, liver diseases, and some renal diseases.
Properties of Aspartate aminotransferase
Density | 1.17 g/mL at 20 °C |
storage temp. | 2-8°C |
form | lyophilized powder |
color | Colorless to light yellow |
EPA Substance Registry System | Aminotransferase, aspartate (9000-97-9) |
Safety information for Aspartate aminotransferase
Computed Descriptors for Aspartate aminotransferase
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